ChemicalBook > CAS DataBase List > 4-Methylsulphonylphenylacetic acid

4-Methylsulphonylphenylacetic acid

Product Name
4-Methylsulphonylphenylacetic acid
CAS No.
90536-66-6
Chemical Name
4-Methylsulphonylphenylacetic acid
Synonyms
TIMTEC-BB SBB009970;Etoricoxib?USP RC B;Etocoxib impurity 2;4-(Methylsulfonyl)ph;Etoricoxib impurity M;OTHER BUILDING BLOCKS;Etoricoxib Impurity 28;4-MESYLPHENYLACETIC ACID;4-Mesylbenzeneacetic acid;Etoricoxib Intermediate 5
CBNumber
CB8339797
Molecular Formula
C9H10O4S
Formula Weight
214.24
MOL File
90536-66-6.mol
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4-Methylsulphonylphenylacetic acid Property

Melting point:
136-140 °C(lit.)
Boiling point:
324.37°C (rough estimate)
Density 
1.4230 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.90±0.10(Predicted)
color 
White to Pale Yellow
Water Solubility 
slight
BRN 
2646649
CAS DataBase Reference
90536-66-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
579114
Product name
4-(Methylsulfonyl)phenylacetic acid
Purity
97%
Packaging
1g
Price
$20
Updated
2023/06/20
Sigma-Aldrich
Product number
579114
Product name
4-(Methylsulfonyl)phenylacetic acid
Purity
97%
Packaging
5g
Price
$21
Updated
2023/06/20
TCI Chemical
Product number
M1899
Product name
4-(Methylsulfonyl)phenylacetic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
M1899
Product name
4-(Methylsulfonyl)phenylacetic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$83
Updated
2024/03/01
Alfa Aesar
Product number
L19504
Product name
4-(Methylsulfonyl)phenylacetic acid, 97%
Packaging
5g
Price
$51.65
Updated
2024/03/01
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4-Methylsulphonylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

yellow to beige-brown crystalline powder

Uses

4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Preparation

synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.

Application

4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.

4-Methylsulphonylphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylsulphonylphenylacetic acid Suppliers

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View Lastest Price from 4-Methylsulphonylphenylacetic acid manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
4-Methylsulphonylphenylacetic acid 90536-66-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99.10%
Supply Ability
5000kg
Release date
2024-04-19
Hebei Yanxi Chemical Co., Ltd.
Product
4-(Methylsulfonyl)phenylacetic acid 90536-66-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-07
Anhui Ruihan Technology Co., Ltd
Product
4-Methylsulphonylphenylacetic acid 90536-66-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11

90536-66-6, 4-Methylsulphonylphenylacetic acidRelated Search:

2-Methylphenylacetic acid 2-Hydroxyphenylacetic acid 4-Methoxyphenylacetic acid Phenethyl phenylacetate 4-Hydroxyphenylacetic acid DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Methyl 2-methylnicotinate 4-(METHYLSULFONYL)PHENYLACETONITRILE Etoricoxib Impurity 18 Etoricoxib Etoricoxib Impurity 15 (Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime Etoricoxib Impurity 31 Etoricoxib iMpurity 1 Etoricoxib IMpurity Etoricoxib Impurity 7 Etoricoxib impurity 22 Etoricoxib Impurity 9

  • TIMTEC-BB SBB009970
  • 4-MESYLPHENYLACETIC ACID
  • 4-(METHANESULFONYL)PHENYLACETIC ACID
  • 4-METHYLSULPHONYLPHENYLACETIC ACID
  • 4-(METHYLSULFONYL)PHENYLACETIC ACID
  • 4-methylsulfonyl benzeneacetic acid
  • 4-(Methylsulfonyl)PhenylAceticAcid,Etoricoxib
  • 4-Methyl Sulphonile Phenyle Acetic Acid
  • 4-(Methanesulfonyl)phenylaceticacid,97%
  • 4-Methylsulfonylphenylacetic
  • Benzeneacetic acid, 4-(methylsulfonyl)-
  • 4-Mesylbenzeneacetic acid
  • 4-Methylsulphonylphenylacetic acid,95%
  • 4-(Methylsulfonyl)ph
  • 2-(4-methylsulfonylphenyl)acetate
  • Etoricoxib?USP RC B
  • 4-(Carboxymethyl)phenyl methyl sulphone
  • Etoricoxib Related CoMpound B
  • Etoricoxib impurity M
  • 4-(Methylsulfonyl)phenylacetic acid 97%
  • Etoricoxib USP Related Compound B
  • Etoricoxib Intermediate 5
  • Etoricoxib Impurity 28
  • 4-(Methylsulfonyl)phenylaceticAcid&gt
  • OTHER BUILDING BLOCKS
  • 4-(Methylsulfonyl)phenylacetic Acid (Int of Etoricoxib)
  • Etocoxib impurity 2
  • 90536-66-6
  • 35230-23-1
  • C9H10O4S
  • H3CSO2C6H4CH2CO2H
  • Carboxylic acid
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • C9
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • Carbonyl Compounds