ChemicalBook > CAS DataBase List > 4-Methylsulphonylphenylacetic acid
4-Methylsulphonylphenylacetic acid
- Product Name
- 4-Methylsulphonylphenylacetic acid
- CAS No.
- 90536-66-6
- Chemical Name
- 4-Methylsulphonylphenylacetic acid
- Synonyms
- TIMTEC-BB SBB009970;Etoricoxib?USP RC B;Etocoxib impurity 2;4-(Methylsulfonyl)ph;Etoricoxib impurity M;OTHER BUILDING BLOCKS;Etoricoxib Impurity 28;4-MESYLPHENYLACETIC ACID;4-Mesylbenzeneacetic acid;Etoricoxib Intermediate 5
- CBNumber
- CB8339797
- Molecular Formula
- C9H10O4S
- Formula Weight
- 214.24
- MOL File
- 90536-66-6.mol
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4-Methylsulphonylphenylacetic acid Property
- Melting point:
- 136-140 °C(lit.)
- Boiling point:
- 324.37°C (rough estimate)
- Density
- 1.4230 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.90±0.10(Predicted)
- color
- White to Pale Yellow
- Water Solubility
- slight
- BRN
- 2646649
- CAS DataBase Reference
- 90536-66-6(CAS DataBase Reference)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 579114
- Product name
- 4-(Methylsulfonyl)phenylacetic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $20
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 579114
- Product name
- 4-(Methylsulfonyl)phenylacetic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $21
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M1899
- Product name
- 4-(Methylsulfonyl)phenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $28
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M1899
- Product name
- 4-(Methylsulfonyl)phenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $83
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L19504
- Product name
- 4-(Methylsulfonyl)phenylacetic acid, 97%
- Packaging
- 5g
- Price
- $51.65
- Updated
- 2024/03/01
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4-Methylsulphonylphenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
yellow to beige-brown crystalline powder
Uses
4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Preparation
synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.
Application
4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.
4-Methylsulphonylphenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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4-Methylsulphonylphenylacetic acid Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
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- Fax
- --
- kanto-61@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 530
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@fine-c.jp
- Country
- Japan
- ProdList
- 1427
- Advantage
- 58
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
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View Lastest Price from 4-Methylsulphonylphenylacetic acid manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- 4-(Methylsulfonyl)phenylacetic acid 90536-66-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-09-07
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- 4-Methylsulphonylphenylacetic Acid 90536-66-6
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
Anhui Ruihan Technology Co., Ltd
- Product
- 4-Methylsulphonylphenylacetic acid 90536-66-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-11
90536-66-6, 4-Methylsulphonylphenylacetic acidRelated Search:
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4-(METHYLSULFONYL)PHENYLACETONITRILE
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Etoricoxib
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(Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime
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