ChemicalBook > CAS DataBase List > 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

Product Name
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
CAS No.
30827-99-7
Chemical Name
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
Synonyms
AEBSF;AEBSF HCL;AEBSF HYDROCHLORIDE;CS-2583;AEBSF HCI;PEFABLOC SC;PEFABLOC(R) SC;AEBSF Solution;PEFABLOC SC PLUS;TIMTEC-BB SBB003219
CBNumber
CB1769137
Molecular Formula
C8H11ClFNO2S
Formula Weight
239.69
MOL File
30827-99-7.mol
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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Property

Melting point:
175-177 °C
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
form 
Powder
color 
White
PH
pH3.0～5.0 (10g/L, 25℃)
Water Solubility 
10 g/L (20 ºC)
Sensitive 
Moisture Sensitive
BRN 
7604627
Stability:
Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
InChIKey
WRDABNWSWOHGMS-UHFFFAOYSA-N
CAS DataBase Reference
30827-99-7(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
45-36/37/39-26-36
RIDADR 
UN 3261
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29214990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
76307
Product name
Pefabloc? SC
Purity
analytical standard
Packaging
100mg
Price
$137
Updated
2024/03/01
Sigma-Aldrich
Product number
76307
Product name
Pefabloc? SC
Purity
analytical standard
Packaging
1g
Price
$902
Updated
2024/03/01
Sigma-Aldrich
Product number
5.32586
Product name
AEBSF,HCl≥99%byHPLC-CAS30827-99-7-Calbiochem
Packaging
250mg
Price
$260
Updated
2024/03/01
Sigma-Aldrich
Product number
101500
Product name
AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem
Purity
AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal
Packaging
100mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
101500
Product name
AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem
Purity
AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal
Packaging
500mg
Price
$504
Updated
2024/03/01
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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties,Usage,Production

Description

AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.

Chemical Properties

white powder

Uses

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Uses

Recommended concentrations for use are 0.1-1 mM.

General Description

Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

Biochem/physiol Actions

Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.

storage

Store at -20°C

References

1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-19
Hebei Weibang Biotechnology Co., Ltd
Product
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Anhui Zhongda Biotechnology Co., Ltd
Product
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride 30827-99-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99%
Supply Ability
100000tons
Release date
2023-08-09

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