ZEARALANONE

ChemicalBook > CAS DataBase List > ZEARALANONE

Product Name: ZEARALANONE
CAS No.: 5975-78-0
Chemical Name: ZEARALANONE
Synonyms: Zanone;P-1502;Ccris 9235;ZEARALANONE;(S)-Zearalanone;Zearalanone solution;Zearalanone Standard;(S)-Zearalanone, P 1502, Zanone;Zearalanone (Certified Reference Material);beta-Resorcylic acid, 6-(10-hydroxy-6-oxoundecyl)-, mu-lactone
CBNumber: CB1769935
Molecular Formula: C18H24O5
Formula Weight: 320.38
MOL File: 5975-78-0.mol

Less

ZEARALANONE Property

Melting point:: 184-186°C
Boiling point:: 576.8±50.0 °C(Predicted)
Density: 1.148±0.06 g/cm3(Predicted)
Flash point:: 2℃
storage temp.: -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 7.83±0.40(Predicted)
color: White to Off-White

Less

Safety

Hazard Codes: Xn,F
Risk Statements: 20/21/22-36/37/38-40-36-11
Safety Statements: 22-26-36-36/37-16
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
HS Code: 29322090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Z0167
Product name: Zearalanone
Packaging: 1mg
Price: $24.28
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32193
Product name: Zearalanone solution
Purity: 10 μg/mL in acetonitrile, analytical standard
Packaging: 1.2ml
Price: $750
Updated: 2022/05/15

Cayman Chemical

Product number: 19459
Product name: Zearalanone
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 19459
Product name: Zearalanone
Purity: ≥98%
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Sigma-Aldrich

Product number: Z0167
Product name: Zearalanone
Packaging: 5mg
Price: $210
Updated: 2024/03/01

Less

ZEARALANONE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

A secondary metabolite of Zearalenone (ZON). The macrocyclic lactone Zearalanone used in the synthesis of d,l-Zearalanol.

Uses

Zearalanone is a minor component of the zearalenone complex produced by several species of Fusarium. Like the more abundant analogues, zearalanone causes estrogenic effects in domestic livestock. Zearalanone is a metabolite of α-zearalanol, a commercially available growth promotant in animals, and is a useful standard for detection of zearanol-contaminated products and Fusarium-contaminated grains.

Definition

ChEBI: Zearalanone is a member of resorcinols and a macrolide.

General Description

Zearalanone (ZEA) or F-2 toxin, a nonsteroidal estrogenic mycotoxin is produced by various Fusarium species. Fusarium graminearum is considered as the primary producer of zearalanone. It is usually seen in moldy hay, high-moisture corn, corn infected before harvest etc.

Biological Activity

zearalanone (zan) is an estrogen receptor agonist and also an androgen receptor antagonist [1].zearalenone (zen), a β-resorcyclic acid lactone (ral), is a non-steroidal estrogenic mycotoxin biosynthesized by several fusarium species. zearalenone (zen) is the well-known mycotoxin present in numerous agricultural products [1][2][3][4]. in the human endometrial ishikawa cell line, zearalenone (zen) exhibited strong oestrogenicity [4].when incubated fusarium semitectum on sorghum, the ratio of zan to zen remained constant after 5 days, suggesting that zan might not be suitable for use as an internal standard [5].zearalanone, a major phase i metabolite of zearalenone (zen), is an estrogen receptor agonist and also an androgen receptor antagonist. in mcf-7 cells, zearalanone strongly induced cell proliferation with ec50 value of 1.21 nm and showed significant estrogenic activity. zearalanone behaved as full herα agonist. in palm cells, zearalanone acted as a har antagonist that strongly inhibited the luciferase activity induced by 0.3 nm of r1881, the synthetic androgen [1].

Biochem/physiol Actions

Zearalanone is believed to cause vulvovaginitis and estrogenic responses in swine.

References

[1]. molina-molina jm, real m, jimenez-diaz i, et al. assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. food chem toxicol.2014 dec;74:233-9.
[2]. baldwin rs, williams rd, terry mk. zeranol: a review of the metabolism, toxicology, and analytical methods for detection of tissue residues. regul toxicol pharmacol. 1983 mar;3(1):9-25.
[3]. migdalof bh, dugger ha, heider jg, et al. biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. xenobiotica. 1983 apr;13(4):209-21.
[4]. le guevel r, pakdel f. assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods. hum reprod. 2001 may;16(5):1030-6.
[5]. aoyama k, ishikuro e, noriduki h, et al. formation ratios of zearalanone, zearalenols, and zearalanols versus zearalenone during incubation of fusarium semitectum on sorghum and ratios in naturally contaminated sorghum. shokuhin eiseigaku zasshi. 2015;56(6):247-51.

ZEARALANONE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

ZEARALANONE Suppliers

Canada 1 China 55 France 1 Germany 1 India 1 Norway 1 Switzerland 1 United Kingdom 1 United States 8 Global 70

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4515
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Qingdao IniKem BioPharmaTech Co.,Ltd

Tel: 18561687109
Fax: -
Email: sales@inikem.com
Country: China
ProdList: 289
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 10016
Advantage: 58

Jiangsu Hongmin Pharmaceutical Co., Ltd.

Tel: 18221292452
Email: fannieliu@glschina.com
Country: China
ProdList: 6799
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038; 18501792038
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9614
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856359 18690052321
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8864
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7975
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11442
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4576
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Lingyuan Bebiansen Biological Technology Co., Ltd

Tel: 18642120371
Email: 2837458851@qq.com
Country: China
ProdList: 9925
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 9946
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31163
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 10066
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 11437
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 18113192475 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 5000
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27996
Advantage: 58

Guangdong Fangxin Biotechnology Co., Ltd.

Tel: 0751-2838688 13376594225
Email: 1276075424@qq.com
Country: China
ProdList: 9934
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 8740
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9241
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb5@aikonchem.com
Country: China
ProdList: 10529
Advantage: 58

Guangzhou Yaoguang Technology Co., Ltd.

Tel: 13020159086
Email: yangjue@ygfuture.com
Country: China
ProdList: 482
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Shanghai Zheyan Biotechnology Co., LTD

Tel: 18017610038 18017610038
Email: 897493074@qq.com
Country: China
ProdList: 5000
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32480
Advantage: 60

ZHEJIANG JIUZHOU CHEM CO., LTD

Tel: +86-0576225566889 +86-13454675544
Email: admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com
Country: China
ProdList: 20000
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6673
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Suzhou Ruinuode Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 2090855807@qq.com
Country: CHINA
ProdList: 6063
Advantage: 58

Shanghai Gaochuang Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: gaochem@163.com
Country: CHINA
ProdList: 6995
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6039
Advantage: 58

Qiyi Biotechnology (Shanghai) Co., Ltd.

Tel: --
Fax: --
Email: qiyibio@163.com
Country: CHINA
ProdList: 6105
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: --
Fax: --
Email: kexianxun@gmail.com
Country: China
ProdList: 1039
Advantage: 50

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Beijing Huayueyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 1365647552@qq.com
Country: CHINA
ProdList: 3655
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Shanghai Shifeng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2279790755@qq.com
Country: CHINA
ProdList: 5572
Advantage: 58

5975-78-0, ZEARALANONERelated Search:

IRONE Zearalenone Zeaxanthin Taleranol-D5 (β-Zearalanol-D5) Zeranol Zeranol-D5(α-Zearalanol-D5) BETA-ZEARALANOL 2,4-Dihydroxybenzoic acid Ethyl 2,4-dihydroxy-6-methylbenzoate ETHYL 2,4-DIHYDROXYBENZOATE 5-Heptylresorcinol Methyl 2,4-dihydroxybenzoate 2-Hydroxybenzoic acid octyl ester Isopropyl salicylate Butyl salicylate 2,4-DIHYDROXY-6-METHYLBENZOIC ACID Octyl paraben Hexyl salicylate

(S)-Zearalanone, P 1502, Zanone

(S)-3,4,5,6,9,10,11,12-Octahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

(S)-Zearalanone

2-[(S)-10-Hydroxy-6-oxoundecyl]-4,6-dihydroxybenzoic acid 1,2-lactone

P-1502

Zanone

1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-, (S)-

beta-Resorcylic acid, 6-(10-hydroxy-6-oxoundecyl)-, mu-lactone

Ccris 9235

Zearalanone,2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone

2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone solution

Zearalanone solution

ZEARALANONE

2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone

2,4-DIHYDROXY-6-[10-HYDROXY-6-OXO-UNDECYL]BENZOIC ACID MICRO-LACTONE

Zearalanone (Certified Reference Material)

Zearalanone Standard

1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-, (3S)-

5975-78-0

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals