FUMONISIN B1
- Product Name
- FUMONISIN B1
- CAS No.
- 116355-83-0
- Chemical Name
- FUMONISIN B1
- Synonyms
- FB1;MACROFUSINE;FUMONISIN B1;B1 Fumonisin B1;Fumonisin B1,96%;FUMONISIN B1 98%;Fumonisin B1 ,95%;Fumonisin B1 (FB1);fumonisin b1solution;FuMonisin B1, 96% 1MG
- CBNumber
- CB1773259
- Molecular Formula
- C34H59NO15
- Formula Weight
- 721.83
- MOL File
- 116355-83-0.mol
FUMONISIN B1 Property
- Melting point:
- >60oC
- Boiling point:
- 713.81°C (rough estimate)
- Density
- 1.2207 (rough estimate)
- refractive index
- 1.6630 (estimate)
- Flash point:
- 6 °C
- storage temp.
- 2-8°C
- solubility
- Soluble in Water (up to 25 mg/ml).
- form
- Powder
- pka
- 3?+-.0.23(Predicted)
- color
- White to tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 116355-83-0
- IARC
- 2B (Vol. 56) 1993, 2B (Vol. 82) 2002
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 40-36-20/21/22-11
- Safety Statements
- 36/37-16-26-45
- RIDADR
- 3172
- WGK Germany
- 3
- RTECS
- TZ8350000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29221990
- Hazardous Substances Data
- 116355-83-0(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- 344850-M
- Product name
- Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem
- Purity
- A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC?? = 100 nM).
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 34139
- Product name
- Fumonisin B1 solution
- Purity
- 50?μg/mL in acetonitrile: water, analytical standard
- Packaging
- 1ML
- Price
- $291
- Updated
- 2024/03/01
- Product number
- 32936
- Product name
- Fumonisin B1
- Purity
- reference material
- Packaging
- 5mg
- Price
- $1260
- Updated
- 2024/03/01
- Product number
- 62580
- Product name
- Fumonisin B1
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 62580
- Product name
- Fumonisin B1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $324
- Updated
- 2024/03/01
FUMONISIN B1 Chemical Properties,Usage,Production
Description
Fumonisin B1 (116355-83-0) inhibits ceramide synthesis (sphinganine N-acyltransferase), IC50 = 100 nM. Inhibits de novo sphingolipid biosynthesis (IC50 = 0.7 μM) thereby blocking glycosphingolipid production.
Chemical Properties
white to tan powder
Uses
A mycotoxin produced by mold associated with corn. Fungal metabolite believed to cause leukoencephalomalacia in horses.
Uses
A serine/threonine phosphatase inhibitor.
Uses
Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons.
Definition
ChEBI: Fumonisin B1 is a diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. It has a role as a metabolite and a carcinogenic agent. It is a fumonisin, a primary amino compound, a diester and a triol. It is functionally related to a (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. It is a conjugate acid of a fumonisin B1(3-).
General Description
Fumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
Biological Activity
Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively.
Biochem/physiol Actions
Fumonisin B1 acts as a hepatocarcinogen and causes hepatotoxicity in rats. In horses, it causes leukoencephalitis, and in pigs, it causes pulmonary edema syndrome. In China and southern parts of Africa, it is linked with high incidence of esophageal cancer in humans. It acts as an inhibitor of sphingosine N-acyltransferase enzyme (ceramide synthase), related to structural similarities between fumonisin B1 and sphingoid bases like sphingosine.
storage
Store at +4°C
References
1) Merrill et al. (1993), Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ; J. Biol. Chem., 268 27299
FUMONISIN B1 Preparation Products And Raw materials
Raw materials
Preparation Products
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