FUMONISIN B1

ChemicalBook > CAS DataBase List > FUMONISIN B1

Product Name: FUMONISIN B1
CAS No.: 116355-83-0
Chemical Name: FUMONISIN B1
Synonyms: FB1;MACROFUSINE;FUMONISIN B1;B1 Fumonisin B1;Fumonisin B1,96%;FUMONISIN B1 98%;Fumonisin B1 ,95%;Fumonisin B1 (FB1);fumonisin b1solution;FuMonisin B1, 96% 1MG
CBNumber: CB1773259
Molecular Formula: C34H59NO15
Formula Weight: 721.83
MOL File: 116355-83-0.mol

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FUMONISIN B1 Property

Melting point:: >60oC
Boiling point:: 713.81°C (rough estimate)
Density: 1.2207 (rough estimate)
refractive index: 1.6630 (estimate)
Flash point:: 6 °C
storage temp.: 2-8°C
solubility: Soluble in Water (up to 25 mg/ml).
form: Powder
pka: 3?+-.0.23(Predicted)
color: White to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference: 116355-83-0
IARC: 2B (Vol. 56) 1993, 2B (Vol. 82) 2002

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 40-36-20/21/22-11
Safety Statements: 36/37-16-26-45
RIDADR: 3172
WGK Germany: 3
RTECS: TZ8350000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29221990
Hazardous Substances Data: 116355-83-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 344850-M
Product name: Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem
Purity: A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC?? = 100 nM).
Packaging: 1mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: 34139
Product name: Fumonisin B1 solution
Purity: 50?μg/mL in acetonitrile: water, analytical standard
Packaging: 1ML
Price: $291
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32936
Product name: Fumonisin B1
Purity: reference material
Packaging: 5mg
Price: $1260
Updated: 2024/03/01

Cayman Chemical

Product number: 62580
Product name: Fumonisin B1
Purity: ≥95%
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 62580
Product name: Fumonisin B1
Purity: ≥95%
Packaging: 5mg
Price: $324
Updated: 2024/03/01

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FUMONISIN B1 Chemical Properties,Usage,Production

Description

Fumonisin B1 (116355-83-0) inhibits ceramide synthesis (sphinganine N-acyltransferase), IC50 = 100 nM. Inhibits de novo sphingolipid biosynthesis (IC50 = 0.7 μM) thereby blocking glycosphingolipid production.

Chemical Properties

white to tan powder

Uses

A mycotoxin produced by mold associated with corn. Fungal metabolite believed to cause leukoencephalomalacia in horses.

Uses

A serine/threonine phosphatase inhibitor.

Uses

Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons.

Definition

ChEBI: Fumonisin B1 is a diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. It has a role as a metabolite and a carcinogenic agent. It is a fumonisin, a primary amino compound, a diester and a triol. It is functionally related to a (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. It is a conjugate acid of a fumonisin B1(3-).

General Description

Fumonisin B₁ is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC₅₀ = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB₁. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.

Biological Activity

Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively.

Biochem/physiol Actions

Fumonisin B1 acts as a hepatocarcinogen and causes hepatotoxicity in rats. In horses, it causes leukoencephalitis, and in pigs, it causes pulmonary edema syndrome. In China and southern parts of Africa, it is linked with high incidence of esophageal cancer in humans. It acts as an inhibitor of sphingosine N-acyltransferase enzyme (ceramide synthase), related to structural similarities between fumonisin B1 and sphingoid bases like sphingosine.

storage

Store at +4°C

References

1) Merrill et al. (1993), Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ; J. Biol. Chem., 268 27299

FUMONISIN B1 Preparation Products And Raw materials

Raw materials

Preparation Products

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FUMONISIN B1 Suppliers

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116355-83-0, FUMONISIN B1Related Search:

FUMONISIN B1 FEMA 2791 Fumonisin B2 STEARYLAMINE ACETATE FEMA 2814 decyl isovalerate Fumonisin B1-13C34 solution Fumonisin B2-13C34 solution FUMONISIN B3 2-AMINONONADECANE fumonisin B4 Fumonisin Fumonisin B3-13C34 solution fumonisin A2 FUMONISIN B2(REAGENT / STANDARD GRADE) FUMONISIN B2(RG) fumonisin C3 fumonisin FP3

MACROFUSINE

FUMONISIN B1

FUMONISIN B1, FUSARIUM MONILIFORME

FB1

1,2,3-PROPANETRICARBOXYLIC ACID 1,1'-[1-(12-AMINO-4,9,11-TRIHYDROXY-2-METHYLTRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANEDIYL] ESTER

1,2,3-PROPANETRICARBOXYLIC ACID 1,1'-[12-AMINO-4,9,11-TRIHYDROXY-2-METHYLTRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANEDIYL]ESTER

1,2,3-propanetricarboxylicacid,1,1’-(1-(12-amino-4,9,11-trihydroxy-2-methyltr

Standard Solution Fumonisin B1

Fumonisin B1 (FB1)

Fumonisin B, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

Fumonisin B1 Ready Made Solution

idecyl)-2-(1-methylpentyl)-1,2-ethanediyl)ester

FUMONISIN B1 (MACROFUSINE) \ SPHINGOSINE

FUMONISIN B1 FROM FUSARIUM MONILIFORME

1,2,3-Propanetricarboxylic acid, 1,1[1-(12-amino-4,9,11-trihydroxy-2-methyl-tridecyl)-2-(1-methylpentyl)-1,2-ethane-diyl]ester, Macrofusine

FumonisinB1 from Fusarium moniliforme, Macrofusine

Fumonisin B1,96%

1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylicacidester.

Fumonisin B1 ,95%

FuMonisin B1, 96% 1MG

(2R,2'R)-1,2,3-Propanetricarboxylic Acid 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-AMino-4,9,11-trihydroxy-2-Methyltridecyl]-2-[(1R)-1-Methylpentyl]-1,2-ethanediyl] Ester

FUMONISIN B1 98%

1,2,3-Propanetricarboxylic acid, 1,1-(1S,2R)-1-(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl-2-(1R)-1-methylpentyl-1,2-ethanediyl ester, (2R,2R)-

fumonisin b1solution

Fumonisin B1 (2R,2'R)-1,2,3-Propanetricarboxylic acid 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester

Fumonisin B1, 96%, from Fusarium moniliforme

Fumonisin B1 Solution [ 50μg/ml Acetonitrile:Water(1:1) Solution]

Fumonisin B1 50ug /ml in ACN:H2O 1:1

B1 Fumonisin B1

(2R)-2-(2-{[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-{[(3R)-3,4-dicarboxybutanoyl]oxy}-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy}-2-oxoethyl)butanedioic acid

Fumonisin B1 50 μg/ml Acetonitrile/Water

Fumonisine B1 in Acetonitrile:Water=1:1

Fumonisine B1 in Acetonitrile

116355-83-0

C34H59NO15

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