Belantamab

Product Name: Belantamab
CAS No.: 2061894-48-0
Chemical Name: Belantamab
Synonyms: GSK2857914;Belantamab;Research Grade Belantamab;Belantamab (anti-TNFRSF17);Research Grade Belantamab(DHF92401)
CBNumber: CB18081093
Formula Weight: 0
MOL File: Mol file

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Belantamab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Belantamab Chemical Properties,Usage,Production

Uses

Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma[1][2].

References

[1] Ivo Demel, et al. Focus on monoclonal antibodies targeting B-cell maturation antigen (BCMA) in multiple myeloma: update 2021. Br J Haematol. 2021 May;193 (4) :705-722. DOI:10.1111/bjh.17235
[2] Montes de Oca R, et al. Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune-mediated Antitumor Responses In Vivo. Mol Cancer Ther. 2021 Oct;20 (10) :1941-1955. DOI:10.1158/1535-7163.MCT-21-0035

Belantamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Belantamab Suppliers

China 17 United States 3 Global 20

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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Changsha Fuzhen Biotechnology Co.，LTD

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Olix (Shanghai) Pharmaceutical Technology Co., Ltd

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Atagenix Laboratories

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Sangon Biotech (Shanghai) Co.,Ltd.

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AntibodySystem Laboratories SAS

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Biosynth Biological Technology (Suzhou) Co Ltd

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Cell Sciences

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Proteintech China

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2061894-48-0, BelantamabRelated Search:

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Belantamab

Research Grade Belantamab(DHF92401)

Belantamab (anti-TNFRSF17)

GSK2857914

Research Grade Belantamab

2061894-48-0