Monalizumab

Product Name: Monalizumab
CAS No.: 1228763-95-8
Chemical Name: Monalizumab
Synonyms: Monalizumab;Monalizumab (anti-NKG2A);Research Grade Monalizumab;Research Grade Monalizumab(DHD71901)
CBNumber: CB58080948
Formula Weight: 0
MOL File: Mol file

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Monalizumab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow
Water Solubility: Soluble in water

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Hazard and Precautionary Statements (GHS)

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Monalizumab Chemical Properties,Usage,Production

Uses

Monalizumab (IPH2201) is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells.

Mechanism of action

Monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.

in vivo

Monalizumab (50 ?μg, intratumoral injections, together with 8?millions of activated NK cells) effectively inhibits tumor growth in xenografted HLA-E⁺ tumors in immunodeficient mice^[4].

Animal Model:	immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell^[4]
Dosage:	50?μg, together with 8?millions of activated NK cells
Administration:	intratumoral injections
Result:	Shows a synergestic antitumor effect. Enhanced NK-cell killing, and induces lysis of tumor cells.

Monalizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Monalizumab Suppliers

China 22 Global 22

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1228763-95-8, MonalizumabRelated Search:

Durvalumab Denosumab Evolocumab Enfortumab Vedotin Avelumab Alirocumab Nivolumab Tislelizumab Toripalimab Lambrolizumab

Monalizumab

Research Grade Monalizumab(DHD71901)

Research Grade Monalizumab

Monalizumab (anti-NKG2A)

1228763-95-8