Rolinsatamab
- Product Name
- Rolinsatamab
- CAS No.
- 2095467-30-2
- Chemical Name
- Rolinsatamab
- Synonyms
- Rolinsatamab;Research Grade Rolinsatamab;Research Grade Rolinsatamab(DHD18001)
- CBNumber
- CB18081109
- Formula Weight
- 0
- MOL File
- Mol file
Rolinsatamab Property
- form
- Liquid
- color
- Colorless to light yellow
Rolinsatamab Chemical Properties,Usage,Production
Uses
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C)[1].
References
[1] Anderson MG, et al. ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition. BMC Cancer. 2021 Jun 9;21(1):681. DOI:10.1186/s12885-021-08403-5
Rolinsatamab Preparation Products And Raw materials
Raw materials
Preparation Products
Rolinsatamab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58