ChemicalBook > CAS DataBase List > L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-

L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-

Product Name
L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
CAS No.
812644-79-4
Chemical Name
L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
Synonyms
TRV056;L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
CBNumber
CB18378344
Molecular Formula
C52H74N14O13
Formula Weight
1103.25
MOL File
812644-79-4.mol
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L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- Property

Density 
1.45±0.1 g/cm3(Predicted)
pka
3.56±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- Chemical Properties,Usage,Production

Uses

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].

IC 50

AT1 Receptor

References

[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005

L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- Suppliers

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812644-79-4, L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-Related Search:

ANGIOTENSIN I/II (4-8) ANGIOTENSIN III, HUMAN ANGIOTENSIN I/II (1-6) ASP-ARG-VAL-TYR (DES-ASP1,ILE8)-ANGIOTENSIN II Angiotensin ANGIOTENSIN I/II (3-7) NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla BZ-GLY-GLY-GLY-OH ANGIOTENSIN I/II (1-5) Angiogenin (108-122) TFA ANGIOTENSIN I, HUMAN H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH ANGIOTENSIN I/II (5-8) ANGIOTENSINOGEN (1-13) (HUMAN) (SAR1,ILE4,8)-ANGIOTENSIN II ANGIOTENSIN III, HUMAN ANGIOTENSIN 1/2 + A (2 - 8)

  • L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
  • TRV056
  • 812644-79-4
  • C52H74N14O13