Tribenoside
- Product Name
- Tribenoside
- CAS No.
- 10310-32-4
- Chemical Name
- Tribenoside
- Synonyms
- TBGF;Venex;Alven;21401-Ba;Glyvenol;Glyvenal;Glivenol;Tohcuron;Ba 21401;Flebosan
- CBNumber
- CB1842212
- Molecular Formula
- C29H34O6
- Formula Weight
- 478.58
- MOL File
- 10310-32-4.mol
Tribenoside Property
- alpha
- D26 +8° (chloroform)
- Boiling point:
- bp1.2 270-280°
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Practically insoluble in water, very soluble in acetone, in methanol and in methylene chloride.
- pka
- 13.01±0.70(Predicted)
- color
- Pale Yellow to Light Yellow
- InChIKey
- ULLNJSBQMBKOJH-VIVFLBMVSA-N
- SMILES
- O(CC)C1O[C@H]([C@@H](COCC2=CC=CC=C2)OCC2=CC=CC=C2)[C@H](OCC2=CC=CC=C2)[C@H]1O
- CAS DataBase Reference
- 10310-32-4
Safety
- Toxicity
- LD50 oral in rat: > 20gm/kg
N-Bromosuccinimide Price
- Product number
- Y0000165
- Product name
- Tribenoside
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000165
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 293301
- Product name
- Ethyl 3,5,6-tri-O-benzyl-D-glucofuranoside
- Packaging
- 5g
- Price
- $382
- Updated
- 2021/12/16
- Product number
- O106695
- Product name
- Ethyl3-5-6-tri-O-benzyl-D-glucofuranoside
- Packaging
- 5G
- Price
- $395
- Updated
- 2021/12/16
- Product number
- ME02540
- Product name
- Ethyl 3,5,6-tri-O-benzyl-D-glucofuranoside
- Packaging
- 50g
- Price
- $425
- Updated
- 2021/12/16
- Product number
- ME02540
- Product name
- Ethyl 3,5,6-tri-O-benzyl-D-glucofuranoside
- Packaging
- 100g
- Price
- $750
- Updated
- 2021/12/16
Tribenoside Chemical Properties,Usage,Production
Description
Tribenoside is the semisynthetic sugar derivate ethyl-3, 5, 6-tri-O-benzyl-D-glucofuranoside, glucose with one ethyl and three benzyl groups. It is widely used in capsule (cps) form for oral administration and cream or suppositories for topical application under several brand names. Tribenoside is indicated for the treatment of chronic venous insufficiency, hemorrhoids, and arthritis. It has a high affinity for the vessel wall and a wide spectrum of pharmacological effects, including venotonic, anti-edematous, fibrinolysis-promoting, analgesic, anti-inflammatory (inhibiting histamine and prostaglandins), anti-allergic, membrane-stabilizing, and bactericidal effects. It regulates the expression and localization of laminins in epidermal cells to reconstruct basement membranes in wound healing[1].
Chemical Properties
Yellowish to pale yellow, clear, viscous liquid.
Originator
Glyvenol,Ciba,W. Germany,1967
Uses
Tribenoside is a vasoprotective drug. It’s used in the treatment of hemorrhoids as it has mild anti-inflammatory and wound healing properties.
Uses
Sclerosing agent.
Definition
ChEBI: (3R,4R,5R)-5-[(1R)-1,2-bis(phenylmethoxy)ethyl]-2-ethoxy-4-phenylmethoxy-3-oxolanol is a glycoside.
Manufacturing Process
4.9 g of 3,5,6-tribenzyl-1,2-isopropylidene glucofuranose are kept overnight at room temperature with 100 cc of N-ethanolic hydrochloric acid. Evaporation under vacuum at below 50°C is then carried out and the residue taken up in 150 cc of chloroform. The chloroform solution is thoroughly washed with sodium bicarbonate solution, dried with calcined sodium sulfate and evaporated under vacuum. The oily residue is then distilled under vacuum with a free flame. In this manner there is obtained the ethyl-3,5,6-tribenzyl_x0002_D-glucofuranoside of boiling point 270°C to 275°C under 1 mm pressure. The glucofuranose used as starting material is obtained as follows: 8.8 g of 1,2-isopropylidene-D-glucofuranose and 50.6 g of benzyl chloride are treated with a total of 28 g of potassium hydroxide in portions with cooling and stirring. The mixture is then stirred for 3 hours at 80°C to 90°C. Working up from chloroform solution and distillation at 250°C to 260°C under 0.1 mm pressure give 8.9 g of 1,2-isopropylidene-3,5,6-tribenzyl-D-glucofuranose.
Therapeutic Function
Topical venotonic
Hazard
Low toxicity by ingestion.
Contact allergens
This drug is used for the treatment, both topical and oral, of hemorrhoids. It leads to benzo?c acid, that is contained in Myroxylon pereirae as well, and could be the sensitizer.
References
[1] S. Zga?arová. “Pathophysiological characterization of drug hypersensitivity to tribenoside.” Central European Journal of Medicine 9 1 (2014): 159–168.
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Raw materials
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View Lastest Price from Tribenoside manufacturers
- Product
- Tribenoside 10310-32-4
- Price
- US $0.00/G
- Min. Order
- 100G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-20
- Product
- Tribenoside 10310-32-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 1000kg
- Release date
- 2023-07-06
- Product
- Tribenoside 10310-32-4
- Price
- US $100.00/kgkg
- Min. Order
- 1kgkg
- Purity
- 0.99
- Supply Ability
- 100
- Release date
- 2023-09-20