ChemicalBook > CAS DataBase List > Dimethoxanate hydrochloride

Dimethoxanate hydrochloride

Product Name
Dimethoxanate hydrochloride
CAS No.
518-63-8
Chemical Name
Dimethoxanate hydrochloride
Synonyms
dimethoxanate hydrochloride;2-(2-Dimethylaminoethoxy)ethyl phenothiazine-10-carboxylate hydrochloride;2-(2-dimethylaminoethyloxy)ethyl phenothiazine-10-carboxylate hydrochloride;phenothiazine-10-carboxylic acid 2-(2-dimethylaminoethyloxy)ethyl ester hydrochloride
CBNumber
CB1910258
Molecular Formula
C19H22N2O3S.ClH
Formula Weight
394.92
MOL File
518-63-8.mol
More
Less

Dimethoxanate hydrochloride Property

Melting point:
161-163 °C (decomp)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD150183
Product name
Dimethoxanate hydrochloride
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD150183
Product name
Dimethoxanate hydrochloride
Packaging
100mg
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD150183
Product name
Dimethoxanate hydrochloride
Packaging
250mg
Price
$210
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD150183
Product name
Dimethoxanate hydrochloride
Packaging
500mg
Price
$365
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0308082
Product name
DIMETHOXANATE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$505.67
Updated
2021/12/16
More
Less

Dimethoxanate hydrochloride Chemical Properties,Usage,Production

Originator

Cothera,Ayerst,US,1957

Manufacturing Process

5.23 g of phenothiazine-10-carboxylic acid chloride were suspended in 8 g of dimethylaminoethoxyethanol and heated, with stirring, under anhydrous conditions, first for 1 hour at a temperature of 50°-105°C, then for another hour at 108°-110°C. All the suspended acid chloride had dissolved after the final heating, and the solution was then allowed to cool slowly to 75°C over a period of one hour. Infrared examination of a sample showed that the esterification reaction was essentially complete after the second hour
The reaction mixture was then poured on 1 liter of crushed ice, and the oily precipitate washed repeatedly by decantation with ice water. It was then taken up in 75 ml of benzene, and again washed repeatedly with water until a pH of 8.2 in the washings indicated that substantially all of the excess β- dimethylaminoethoxyethanol had been removed. The benzene solution was then dried with anhydrous sodium sulfate, filtered, and the benzene evaporated in a current of dry nitrogen gas. The residual dark oil constituted the desired basic ester. β-Dimethylaminoethoxyethyl phenothiazine-10- carboxylate.
The basic ester may be dissolved in anhydrous ether and then precipitated by adding a slight excess of a solution of dry hydrogen chloride in ether and the hydrochloride salt may be isolated as an amorphous, glasslike product, which could be crystallized from anhydrous acetone or from methanol-ether. In this manner there was obtained as a stable, crystalline, colorless substance β- dimethylaminoethoxyethyl phenothiazine-10-carboxylate hydrochloride, one sample of which melted at 161°-163°C with decomposition.

Therapeutic Function

Antitussive

Dimethoxanate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Dimethoxanate hydrochloride Suppliers

China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39894
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 15319487004
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
3942
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-61856358 15229202216
Fax
029-88380327
Email
1020@dideu.com
Country
China
ProdList
10011
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Email
sales@coreychem.com
Country
China
ProdList
29880
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49978
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
More
Less

View Lastest Price from Dimethoxanate hydrochloride manufacturers

Career Henan Chemical Co
Product
Dimethoxanate hydrochloride 518-63-8
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

518-63-8, Dimethoxanate hydrochlorideRelated Search:


  • dimethoxanate hydrochloride
  • 2-(2-Dimethylaminoethoxy)ethyl phenothiazine-10-carboxylate hydrochloride
  • 2-(2-dimethylaminoethyloxy)ethyl phenothiazine-10-carboxylate hydrochloride
  • phenothiazine-10-carboxylic acid 2-(2-dimethylaminoethyloxy)ethyl ester hydrochloride
  • 518-63-8
  • C19H22N2O3SHCl
  • API