protizinic acid
- Product Name
- protizinic acid
- CAS No.
- 13799-03-6
- Chemical Name
- protizinic acid
- Synonyms
- Pirocrid;ENC2374530;Protizinic;protizinic acid;7-Methoxy-α,10-dimethyl-10H-phenothiazine-2-acetic acid;10H-Phenothiazine-2-acetic acid, 7-methoxy-α,10-dimethyl-;2-(7-Methoxy-10-methyl-10H-phenothiazin-2-yl)propionic acid
- CBNumber
- CB1916164
- Molecular Formula
- C17H17NO3S
- Formula Weight
- 315.39
- MOL File
- 13799-03-6.mol
protizinic acid Property
- Melting point:
- 124-125 °C
- Boiling point:
- 524.6±50.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- pka
- 4.14±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- API0003965
- Product name
- PROTIZINIC ACID
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1637.21
- Updated
- 2021/12/16
protizinic acid Chemical Properties,Usage,Production
Uses
Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM[1][2].
Definition
ChEBI: Protizinic acid is an organic molecular entity.
in vivo
In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed[1].
Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs[2].
IC 50
PLA2: 210 μM (IC50)
References
[1] K Suzuki, et al. Effects of protizinic acid on leukokinin generation and its physiological action. Agents Actions. 1984 Jun;14(5-6):699-706. DOI:10.1007/BF01978911
[2] H Ohnishi, et al. Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals. Nihon Yakurigaku Zasshi. 1982 Jun;79(6):561-9. PMID:6290356
protizinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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