4-Bromo-6-fluoroquinoline

Product Name: 4-Bromo-6-fluoroquinoline
CAS No.: 661463-17-8
Chemical Name: 4-Bromo-6-fluoroquinoline
Synonyms: 4-Bromo-6-fluoroquinoline;Quinoline, 4-bromo-6-fluoro-
CBNumber: CB1948011
Molecular Formula: C9H5BrFN
Formula Weight: 226.05
MOL File: 661463-17-8.mol

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4-Bromo-6-fluoroquinoline Property

Boiling point:: 299.7±20.0 °C(Predicted)
Density: 1.647±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 2.71±0.16(Predicted)
Appearance: Colorless to yellow Solid
InChIKey: HIWPTYUKGHNQCU-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000278
Product name: 4-Bromo-6-fluoroquinoline
Purity: Aldrich
Packaging: 1g
Price: $356
Updated: 2025/07/31

TRC

Product number: B804385
Product name: 4-bromo-6-fluoroquinoline
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC404567
Product name: 4-Bromo-6-fluoroquinoline
Packaging: 1g
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: 7568BB
Product name: 4-Bromo-6-fluoroquinoline
Packaging: 5g
Price: $377
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-B-0G
Product name: 4-Bromo-6-fluoroquinoline
Packaging: 1g
Price: $456
Updated: 2021/12/16

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4-Bromo-6-fluoroquinoline Chemical Properties,Usage,Production

Synthesis

391-78-6

661463-17-8

General procedure for the synthesis of 4-bromo-6-fluoroquinoline from 4-hydroxy-6-fluoroquinoline: To a solution of 4-hydroxy-6-fluoroquinoline (20 g, 122.58 mmol) in DMF (130 mL) heated to 60 °C was slowly added phosphorus tribromide (13 mL, 1.15 equiv.). The reaction mixture was heated at 45 °C with stirring for 45 min. After the reaction was completed, it was cooled to room temperature and the reaction solution was diluted with water (200 mL). Subsequently, Na2CO3 was slowly added until the pH of the reaction solution reached 10. The precipitated solid product was collected by filtration. The solid was dissolved in ethyl acetate (200 mL) and the solution was concentrated to dryness. The residue was purified by column chromatography (eluent: ethyl acetate) to afford the target product 4-bromo-6-fluoroquinoline as a pale yellow solid (22 g, 79% yield).1H NMR (CDCl3) δ: 8.70 (d, J = 4.7 Hz, 1H); 8.14 (m, 1H); 7.96 (d, J = 4.7 Hz, 1H); 7.81-7.73 (m 2H).

References

[1] Patent: WO2008/152603, 2008, A1. Location in patent: Page/Page column 36
[2] Patent: WO2017/21319, 2017, A1. Location in patent: Page/Page column 32

4-Bromo-6-fluoroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-6-fluoroquinoline Suppliers

China 85 India 2 United Kingdom 1 United States 4 Global 92

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

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Email: info@hanhongsci.com
Country: China
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Advantage: 64

Wuhan ariel chemical Co., LTD.

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Fax: 027-87840182
Email: sales@3stc.com
Country: China
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Advantage: 58

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Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1999
Advantage: 58

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Country: China
ProdList: 9510
Advantage: 58

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Country: China
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Wuhan Kaymke Chemical Co., Ltd.,

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Fax: 027-87342388
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Country: China
ProdList: 3731
Advantage: 55

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
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Bide Pharmatech Ltd.

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Suzhou Laing Biological Technology Co., LTD

Tel: 0512-62968256 18550502935
Fax: 0512-62968256
Email: export@laingbiotec.com
Country: China
ProdList: 981
Advantage: 58

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View Lastest Price from 4-Bromo-6-fluoroquinoline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Bromo-6-fluoroquinoline 661463-17-8
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 4-Bromo-6-fluoroquinoline 661463-17-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

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4-Bromo-6-fluoroquinoline

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661463-17-8