4-Bromo-6-fluoroquinoline
- Product Name
- 4-Bromo-6-fluoroquinoline
- CAS No.
- 661463-17-8
- Chemical Name
- 4-Bromo-6-fluoroquinoline
- Synonyms
- 4-Bromo-6-fluoroquinoline;Quinoline, 4-bromo-6-fluoro-
- CBNumber
- CB1948011
- Molecular Formula
- C9H5BrFN
- Formula Weight
- 226.05
- MOL File
- 661463-17-8.mol
4-Bromo-6-fluoroquinoline Property
- Boiling point:
- 299.7±20.0 °C(Predicted)
- Density
- 1.647±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 2.71±0.16(Predicted)
- Appearance
- Colorless to yellow Solid
- InChIKey
- HIWPTYUKGHNQCU-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BBO000278
- Product name
- 4-Bromo-6-fluoroquinoline
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $356
- Updated
- 2025/07/31
- Product number
- B804385
- Product name
- 4-bromo-6-fluoroquinoline
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC404567
- Product name
- 4-Bromo-6-fluoroquinoline
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 7568BB
- Product name
- 4-Bromo-6-fluoroquinoline
- Packaging
- 5g
- Price
- $377
- Updated
- 2021/12/16
- Product number
- 3H32-B-0G
- Product name
- 4-Bromo-6-fluoroquinoline
- Packaging
- 1g
- Price
- $456
- Updated
- 2021/12/16
4-Bromo-6-fluoroquinoline Chemical Properties,Usage,Production
Synthesis
391-78-6
661463-17-8
General procedure for the synthesis of 4-bromo-6-fluoroquinoline from 4-hydroxy-6-fluoroquinoline: To a solution of 4-hydroxy-6-fluoroquinoline (20 g, 122.58 mmol) in DMF (130 mL) heated to 60 °C was slowly added phosphorus tribromide (13 mL, 1.15 equiv.). The reaction mixture was heated at 45 °C with stirring for 45 min. After the reaction was completed, it was cooled to room temperature and the reaction solution was diluted with water (200 mL). Subsequently, Na2CO3 was slowly added until the pH of the reaction solution reached 10. The precipitated solid product was collected by filtration. The solid was dissolved in ethyl acetate (200 mL) and the solution was concentrated to dryness. The residue was purified by column chromatography (eluent: ethyl acetate) to afford the target product 4-bromo-6-fluoroquinoline as a pale yellow solid (22 g, 79% yield).1H NMR (CDCl3) δ: 8.70 (d, J = 4.7 Hz, 1H); 8.14 (m, 1H); 7.96 (d, J = 4.7 Hz, 1H); 7.81-7.73 (m 2H).
References
[1] Patent: WO2008/152603, 2008, A1. Location in patent: Page/Page column 36
[2] Patent: WO2017/21319, 2017, A1. Location in patent: Page/Page column 32
4-Bromo-6-fluoroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-6-fluoroquinoline Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 4-Bromo-6-fluoroquinoline manufacturers
- Product
- 4-Bromo-6-fluoroquinoline 661463-17-8
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 4-Bromo-6-fluoroquinoline 661463-17-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07