Methyl 3-chloro-5-nitrobenzoate
- Product Name
- Methyl 3-chloro-5-nitrobenzoate
- CAS No.
- 36138-28-0
- Chemical Name
- Methyl 3-chloro-5-nitrobenzoate
- Synonyms
- Methyl 3-chloro-5-nitrobenzoate;Methyl3-chloro-5-nitrobenzoate98%;Methyl 3-chloro-5-nitrobenzoate 98%;Benzoic acid, 3-chloro-5-nitro-, Methyl ester;3-chloro-5-nitro-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 3-chloro-5-nitro-, methyl ester (9CI, ACI)
- CBNumber
- CB1956454
- Molecular Formula
- C8H6ClNO4
- Formula Weight
- 215.59
- MOL File
- 36138-28-0.mol
Methyl 3-chloro-5-nitrobenzoate Property
- Boiling point:
- 314.0±22.0 °C(Predicted)
- Density
- 1.426±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to gray Solid
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M295705
- Product name
- Methyl3-chloro-5-nitrobenzoate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 4654-5-Y5
- Product name
- Methyl 3-chloro-5-nitrobenzoate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 4654-5-Y5
- Product name
- Methyl 3-chloro-5-nitrobenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 4654-5-Y5
- Product name
- Methyl 3-chloro-5-nitrobenzoate
- Purity
- 98%
- Packaging
- 5G
- Price
- $280
- Updated
- 2021/12/16
- Product number
- X5417
- Product name
- Methyl3-chloro-5-nitrobenzoate
- Packaging
- 10g
- Price
- $342
- Updated
- 2021/12/16
Methyl 3-chloro-5-nitrobenzoate Chemical Properties,Usage,Production
Synthesis
67-56-1
34662-36-7
36138-28-0
Step 1: 3-amino-5-nitrobenzoic acid was dissolved in concentrated hydrochloric acid to prepare a 0.09 M solution. To this solution, 7.0 equivalents of aqueous NaNO2 (0.96 M) was slowly added at 0°C. After gradually warming the reaction mixture to room temperature over 30 minutes, 10.0 equivalents of aqueous CuCl solution (1.37 M) was added. The reaction mixture was stirred at room temperature for 3 hours and subsequently heated to 70 °C and kept for 30 minutes. After completion of the reaction, ether and water were added to separate the organic phase and the aqueous phase was extracted with ether. The organic layers were combined, dried and the solvent was evaporated to give a solid product (MS (ES+) m/z 200,202 (M+H)+). The solid was dissolved in methanol to prepare a 0.1 M solution. To this solution 20 equivalents of SOCl2 was added and the reaction mixture was heated at 80 °C for 16 hours. At the end of the reaction, the solvent was evaporated and the residue was dissolved in ethyl acetate and saturated aqueous NaHCO3 solution. The aqueous phase was separated and the organic phase was washed sequentially with saturated aqueous NaHCO3 and brine, dried and the solvent was evaporated to give the title compound methyl 3-chloro-5-nitrobenzoate in 95% yield as a white solid (MS (ES+) m/z 216,218 (M+H)+).
References
[1] Patent: WO2007/28789, 2007, A1. Location in patent: Page/Page column 35
Methyl 3-chloro-5-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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