3,5-DIFLUORO-4-FORMYLBENZONITRILE
- Product Name
- 3,5-DIFLUORO-4-FORMYLBENZONITRILE
- CAS No.
- 467442-15-5
- Chemical Name
- 3,5-DIFLUORO-4-FORMYLBENZONITRILE
- Synonyms
- 4-Cyano-2,6-difluorobezaldehyde;1-(6-chloropyridin-4-yl)ethanone;3,5-DIFLUORO-4-FORMYLBENZONITRILE;Benzonitrile, 3,5-difluoro-4-formyl-;3,5-Difluoro-4-formylbenzonitrile 97%;3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97%;3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97% ISO 9001：2015 REACH;3,5-Difluoro-4-forMylbenzonitrile[4-Cyano-2,6-difluorobenzaldehyde]
- CBNumber
- CB1972917
- Molecular Formula
- C8H3F2NO
- Formula Weight
- 167.11
- MOL File
- 467442-15-5.mol
3,5-DIFLUORO-4-FORMYLBENZONITRILE Property
- Melting point:
- 97-101 °C
- Boiling point:
- 261.9±40.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 673048
- Product name
- 3,5-Difluoro-4-formylbenzonitrile
- Purity
- 97%
- Packaging
- 500mg
- Price
- $124
- Updated
- 2023/01/07
- Product number
- D420155
- Product name
- 3,5-Difluoro-4-formylbenzonitrile
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- D420155
- Product name
- 3,5-Difluoro-4-formylbenzonitrile
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W6401
- Product name
- 3,5-Difluoro-4-formylbenzonitrile
- Packaging
- 250mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- PC911293
- Product name
- 3,5-Difluoro-4-formylbenzonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
3,5-DIFLUORO-4-FORMYLBENZONITRILE Chemical Properties,Usage,Production
Synthesis
64248-63-1
68-12-2
467442-15-5
Under nitrogen protection, 2.5 M tert-butyllithium (4.4 mL) was slowly added dropwise to a stirred solution of N,N-diisopropylethylamine (1.1 g, 11 mmol) in anhydrous tetrahydrofuran (100 mL), keeping the reaction temperature at -78 °C. The reaction system was then slowly warmed to 0 °C and stirred continuously for 1 hour. After that, the reaction solution was re-cooled to -78 °C and 3,5-difluorobenzonitrile (1.39 g, 10 mmol) was added. After continued stirring at -78 °C for 1 h, N,N-dimethylformamide (877 mg, 12 mmol) was added to the reaction solution and the reaction was carried out for 0.5 h. The reaction was carried out at -78 °C for 0.5 h. Upon completion of the reaction, the reaction was quenched by the addition of 10% v/v aqueous acetic acid (20 mL). The reaction mixture was gradually warmed up to room temperature, extracted with ethyl acetate, and concentrated under reduced pressure after combining the organic phases to afford 3,5-difluoro-4-formylbenzonitrile (1.29 g, 77% yield) as a yellow solid.
References
[1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[2] Patent: WO2013/174895, 2013, A1. Location in patent: Page/Page column 66
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 17, p. 4575 - 4579
[4] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 68
[5] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0413
3,5-DIFLUORO-4-FORMYLBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-DIFLUORO-4-FORMYLBENZONITRILE manufacturers
- Product
- 3,5-DIFLUORO-4-FORMYLBENZONITRILE 467442-15-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-02