ChemicalBook > CAS DataBase List > 3,5-DIFLUORO-4-FORMYLBENZONITRILE

3,5-DIFLUORO-4-FORMYLBENZONITRILE

Product Name: 3,5-DIFLUORO-4-FORMYLBENZONITRILE
CAS No.: 467442-15-5
Chemical Name: 3,5-DIFLUORO-4-FORMYLBENZONITRILE
Synonyms: 4-Cyano-2,6-difluorobezaldehyde;1-(6-chloropyridin-4-yl)ethanone;3,5-DIFLUORO-4-FORMYLBENZONITRILE;Benzonitrile, 3,5-difluoro-4-formyl-;3,5-Difluoro-4-formylbenzonitrile 97%;3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97%;3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97% ISO 9001：2015 REACH;3,5-Difluoro-4-forMylbenzonitrile[4-Cyano-2,6-difluorobenzaldehyde]
CBNumber: CB1972917
Molecular Formula: C8H3F2NO
Formula Weight: 167.11
MOL File: 467442-15-5.mol

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3,5-DIFLUORO-4-FORMYLBENZONITRILE Property

Melting point:: 97-101 °C
Boiling point:: 261.9±40.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 673048
Product name: 3,5-Difluoro-4-formylbenzonitrile
Purity: 97%
Packaging: 500mg
Price: $124
Updated: 2023/01/07

TRC

Product number: D420155
Product name: 3,5-Difluoro-4-formylbenzonitrile
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D420155
Product name: 3,5-Difluoro-4-formylbenzonitrile
Packaging: 250mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: W6401
Product name: 3,5-Difluoro-4-formylbenzonitrile
Packaging: 250mg
Price: $108
Updated: 2021/12/16

Apolloscientific

Product number: PC911293
Product name: 3,5-Difluoro-4-formylbenzonitrile
Purity: 95%
Packaging: 1g
Price: $360
Updated: 2021/12/16

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3,5-DIFLUORO-4-FORMYLBENZONITRILE Chemical Properties,Usage,Production

Synthesis

64248-63-1

68-12-2

467442-15-5

Under nitrogen protection, 2.5 M tert-butyllithium (4.4 mL) was slowly added dropwise to a stirred solution of N,N-diisopropylethylamine (1.1 g, 11 mmol) in anhydrous tetrahydrofuran (100 mL), keeping the reaction temperature at -78 °C. The reaction system was then slowly warmed to 0 °C and stirred continuously for 1 hour. After that, the reaction solution was re-cooled to -78 °C and 3,5-difluorobenzonitrile (1.39 g, 10 mmol) was added. After continued stirring at -78 °C for 1 h, N,N-dimethylformamide (877 mg, 12 mmol) was added to the reaction solution and the reaction was carried out for 0.5 h. The reaction was carried out at -78 °C for 0.5 h. Upon completion of the reaction, the reaction was quenched by the addition of 10% v/v aqueous acetic acid (20 mL). The reaction mixture was gradually warmed up to room temperature, extracted with ethyl acetate, and concentrated under reduced pressure after combining the organic phases to afford 3,5-difluoro-4-formylbenzonitrile (1.29 g, 77% yield) as a yellow solid.

References

[1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[2] Patent: WO2013/174895, 2013, A1. Location in patent: Page/Page column 66
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 17, p. 4575 - 4579
[4] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 68
[5] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0413

3,5-DIFLUORO-4-FORMYLBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-DIFLUORO-4-FORMYLBENZONITRILE Suppliers

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View Lastest Price from 3,5-DIFLUORO-4-FORMYLBENZONITRILE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-DIFLUORO-4-FORMYLBENZONITRILE 467442-15-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-02

467442-15-5, 3,5-DIFLUORO-4-FORMYLBENZONITRILERelated Search:

4-CYANO-2,6-DIFLUOROBENZOIC ACID 4-cyano-2,3,5,6-tetrafluorobenzoic acid 4-CYANO-2-FLUOROBENZALDEHYDE 3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97%

3,5-Difluoro-4-formylbenzonitrile 97%

3,5-Difluoro-4-forMylbenzonitrile[4-Cyano-2,6-difluorobenzaldehyde]

Benzonitrile, 3,5-difluoro-4-formyl-

3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97% ISO 9001：2015 REACH

4-Cyano-2,6-difluorobezaldehyde

1-(6-chloropyridin-4-yl)ethanone

3,5-DIFLUORO-4-FORMYLBENZONITRILE

3,5-DIFLUORO-4-FORMYLBENZONITRILE, 97%

467442-15-5

Aldehydes

Carbonyl Compounds