2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
- Product Name
- 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 15224-11-0
- Chemical Name
- 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-(hydroxyMethyl)cyclopropanecarboxylate;ethyl 2‐(hydroxymethyl)cyclopropane‐1‐carboxylate;trans-ethyl 2-hydroxymethyl-1-cyclopropanecarboxylate;Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-, ethyl ester
- CBNumber
- CB21010118
- Molecular Formula
- C7H12O3
- Formula Weight
- 144.17
- MOL File
- 15224-11-0.mol
2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Property
- Boiling point:
- 205.9±13.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 15.10±0.10(Predicted)
- Appearance
- colourless to yellow liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H633135
- Product name
- 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CHM0092532
- Product name
- 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.74
- Updated
- 2021/12/16
- Product number
- 1740AJ
- Product name
- 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
- Packaging
- 5g
- Price
- $1874
- Updated
- 2021/12/16
- Product number
- 05R0547
- Product name
- 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
- Purity
- 97%
- Packaging
- 5g
- Price
- $1992
- Updated
- 2021/12/16
- Product number
- 05R0547
- Product name
- 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
- Purity
- 97%
- Packaging
- 50mg
- Price
- $125
- Updated
- 2021/12/16
2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
13949-93-4
15224-11-0
Step 1: To a solution of ethyl rel-(1R,2R)-2-formylcyclopropanecarboxylate (2.00 g, 13.68 mmol) in anhydrous ethanol (55.0 mL) was added sodium borohydride (0.776 g, 20.53 mmol) in one portion at room temperature and anhydrous conditions. The reaction mixture was stirred at room temperature for 5 h. Subsequently, the reaction was quenched with phosphate buffer aqueous solution (100 mL) at pH 7 and the ethanol was removed by distillation under reduced pressure. The remaining aqueous phase was decanted with dichloromethane (100 mL) followed by further extraction with dichloromethane (2 x 100 mL). The organic phases were combined and washed sequentially with phosphate buffered aqueous solution (70 mL) and saturated saline (70 mL) at pH 7. After drying with anhydrous magnesium sulfate, the product was filtered and concentrated to afford ethyl 2-(hydroxymethyl)cyclopropanecarboxylate (C-5) as a light-yellow oil (1.334 g, 68% yield), which was ready for use in the subsequent steps without further purification. Mass spectrometry analysis showed [M + 1] peak: m/e 145.
References
[1] Patent: WO2005/23818, 2005, A2. Location in patent: Page/Page column 136
[2] Patent: US2011/224137, 2011, A1
[3] Patent: WO2011/106273, 2011, A1. Location in patent: Page/Page column 71; 72
[4] Patent: WO2011/53519, 2011, A1. Location in patent: Page/Page column 26
[5] Patent: WO2013/170030, 2013, A1. Location in patent: Page/Page column 75
2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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