2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER

Product Name: 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
CAS No.: 15224-11-0
Chemical Name: 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethyl 2-(hydroxyMethyl)cyclopropanecarboxylate;ethyl 2‐(hydroxymethyl)cyclopropane‐1‐carboxylate;trans-ethyl 2-hydroxymethyl-1-cyclopropanecarboxylate;Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-, ethyl ester
CBNumber: CB21010118
Molecular Formula: C7H12O3
Formula Weight: 144.17
MOL File: 15224-11-0.mol

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2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Property

Boiling point:: 205.9±13.0 °C(Predicted)
Density: 1.144±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.10±0.10(Predicted)
Appearance: colourless to yellow liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H633135
Product name: 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
Packaging: 100mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0092532
Product name: 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $498.74
Updated: 2021/12/16

AK Scientific

Product number: 1740AJ
Product name: 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
Packaging: 5g
Price: $1874
Updated: 2021/12/16

J&W Pharmlab

Product number: 05R0547
Product name: 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
Purity: 97%
Packaging: 50mg
Price: $125
Updated: 2021/12/16

J&W Pharmlab

Product number: 05R0547
Product name: 2-Hydroxymethyl-cyclopropanecarboxylicacidethylester
Purity: 97%
Packaging: 100mg
Price: $149
Updated: 2021/12/16

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2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

13949-93-4

15224-11-0

Step 1: To a solution of ethyl rel-(1R,2R)-2-formylcyclopropanecarboxylate (2.00 g, 13.68 mmol) in anhydrous ethanol (55.0 mL) was added sodium borohydride (0.776 g, 20.53 mmol) in one portion at room temperature and anhydrous conditions. The reaction mixture was stirred at room temperature for 5 h. Subsequently, the reaction was quenched with phosphate buffer aqueous solution (100 mL) at pH 7 and the ethanol was removed by distillation under reduced pressure. The remaining aqueous phase was decanted with dichloromethane (100 mL) followed by further extraction with dichloromethane (2 x 100 mL). The organic phases were combined and washed sequentially with phosphate buffered aqueous solution (70 mL) and saturated saline (70 mL) at pH 7. After drying with anhydrous magnesium sulfate, the product was filtered and concentrated to afford ethyl 2-(hydroxymethyl)cyclopropanecarboxylate (C-5) as a light-yellow oil (1.334 g, 68% yield), which was ready for use in the subsequent steps without further purification. Mass spectrometry analysis showed [M + 1] peak: m/e 145.

References

[1] Patent: WO2005/23818, 2005, A2. Location in patent: Page/Page column 136
[2] Patent: US2011/224137, 2011, A1
[3] Patent: WO2011/106273, 2011, A1. Location in patent: Page/Page column 71; 72
[4] Patent: WO2011/53519, 2011, A1. Location in patent: Page/Page column 26
[5] Patent: WO2013/170030, 2013, A1. Location in patent: Page/Page column 75

2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER Suppliers

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15224-11-0, 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTERRelated Search:

Cyclopropyl carbinol 1-FLUOROCYCLOPROPANE-1,2-DICARBOXYLIC ACID 1-ETHYL ESTER Cyclopropane-1,1,2,2,3,3-hexacarboxylicacidhexamethylester TRANS-DIETHYL CARONATE DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE RARECHEM AL BF 0655 DIETHYL 3-([3-(TRIFLUOROMETHYL)ANILINO]CARBONYL)-1,2-CYCLOPROPANEDICARBOXYLATE RARECHEM AL BP 0655 (1S,2S)-CYCLOPROPANE-1,2-DICARBOXYLIC ACID BIS-((1R,2S,5R)-2-ISOPROPYL-5-METHYL-CYCLOHEXYL) ESTER (1S,2S)-TRANS-1,2-CYCLOPROPANE DICARBOXYLIC ACID DIETHYL ESTER CIS, TRANS, TRANS-3,5-DIOXA-BICYCLO[5.1.0]OCTANE-8-CARBOXYLIC ACID ETHYL ESTER DIETHYL 3-[[(TRIFLUOROMETHYL)AMINO]CARBONYL]-1,2-CYCLOPROPANEDICARBOXYLATE (1R,2R)-TRANS-1,2-CYCLOPROPANE DICARBOXYLIC ACID MONOETHYL ESTER DIETHYL TRANS-1,2-CYCLOPROPANEDICARBOXYLATE 1,2-Cyclopropanedicarboxylicacid,monoethylester(9CI) 2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER

Ethyl 2-(hydroxyMethyl)cyclopropanecarboxylate

ethyl 2‐(hydroxymethyl)cyclopropane‐1‐carboxylate

trans-ethyl 2-hydroxymethyl-1-cyclopropanecarboxylate

Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-, ethyl ester

15224-11-0