ChemicalBook > CAS DataBase List > Pipobroman
Pipobroman
- Product Name
- Pipobroman
- CAS No.
- 54-91-1
- Chemical Name
- Pipobroman
- Synonyms
- Amedel;A-8103;Vercyte;NSC-25154;Pipobroman;Pipobroman, 10 mM in DMSO;1,4-Bis(3-bromopropionyl)piperazine;1,4-Bis(3-bromo-1-oxopropyl)piperadine;1,4-Bis(3-bromo-1-oxopropyl)piperazine;1,1'-(1,4-Piperazinediyl)bis[3-bromo]-1-propanone
- CBNumber
- CB21016761
- Molecular Formula
- C10H16Br2N2O2
- Formula Weight
- 356.05
- MOL File
- 54-91-1.mol
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Pipobroman Property
- Melting point:
- 106-107℃
- Boiling point:
- 487℃
- Density
- 1.691
- refractive index
- 1.6220 (estimate)
- Flash point:
- 248℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- -0.56±0.70(Predicted)
- color
- Crystals from H2O
- EPA Substance Registry System
- Pipobroman (54-91-1)
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Safety
- Hazardous Substances Data
- 54-91-1(Hazardous Substances Data)
- Toxicity
- LD50 orl-rat: 220 mg/kg IYKEDH 4,467,73
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3602
- Product name
- Pipobroman
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $67.64
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML3602
- Product name
- Pipobroman
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $288
- Updated
- 2025/07/31
TRC
- Product number
- P490600
- Product name
- Pipobroman
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 099654
- Product name
- 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
- Purity
- 95+%
- Packaging
- 5g
- Price
- $975
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 099654
- Product name
- 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1650
- Updated
- 2021/12/16
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Pipobroman Chemical Properties,Usage,Production
Originator
Vercyte ,Abbott ,US ,1966
Uses
diuretic, antihypertensive
Definition
ChEBI: Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an antineoplastic agent and an alkylating agent. It is a N-acylpiperazine, a tertiary carboxamide and an organobromine compound.
Manufacturing Process
To a solution of 17.2 g (0.10 mol) of 3-bromopropionyl chloride in 100 ml of anhydrous benzene was added dropwise with stirring a solution of 8.6 g (0.10 mol) of anhydrous piperazine in 20 ml of dry chloroform over a period of 30 minutes. The temperature rose spontaneously to 45°C during the addition. After the temperature ceased to rise, stirring was continued for another hour. The reaction mixture was then filtered to remove the piperazine hydrochloride by-product. The filtrate was evaporated to dryness and the residue recrystallized from ethanol to obtain the desired N,N'-bis-(3bromopropionyl)piperazine as a white crystalline solid melting at 103°C to 104°C. The identity of the product was further established by elemental analysis.
brand name
Vercyte (Abbott).
Therapeutic Function
Antineoplastic
Biological Activity
Pipobroman is an alkylating agent th at is used as anti-cancer drug. It also has clinical activity in polycythemia vera and thrombocythemia.
Safety Profile
Poison by ingestion,subcutaneous and intraperitoneal routes. An experimentalteratogen. Other experimental reproductive effects.Human mutation data reported. When heated todecomposition it emits very toxic fumes of Br- and NOx.
Pipobroman Preparation Products And Raw materials
Raw materials
Preparation Products
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54-91-1, PipobromanRelated Search:
N-PENTADECANE
1-Bromopropane
Methyl bromide
1-Bromo-2-methylpropane
Piperazine, 1,4-diacetyl- (6CI,8CI,9CI)
3-bromo-N,N-diethylpropan-1-amine hydrobromide
(3-BROMO-PROPYL)-DIMETHYL-AMINE
1-N-PROPYLPIPERAZINE DIHYDROBROMIDE
PIPERAZINE, 1-(3-BROMOPROPYL)-4-METHYL-, HYDROBROMIDE (1:1)
1-PROPYL-PIPERAZINE MONOHYDROBROMIDE
Pipobroman