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Amprolium Hydrochloride

Product Name
Amprolium Hydrochloride
CAS No.
137-88-2
Chemical Name
Amprolium Hydrochloride
Synonyms
AMPROLIUM HCL;Amprolio;2-picolinium,1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-,chloride,monohydroc;amprol;amprol25;mepyrium;Amprovine;Ampomycin;CB2101848;thiacoccid
CBNumber
CB2101848
Molecular Formula
C14H20Cl2N4
Formula Weight
315.24
MOL File
137-88-2.mol
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Amprolium Hydrochloride Property

Melting point:
239.0 to 243.0 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly), Water (Slightly)
form 
Powder
color 
White to Off-white
BRN 
4118699
InChI
InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
InChIKey
PJBQYZZKGNOKNJ-UHFFFAOYSA-M
SMILES
C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-]
CAS DataBase Reference
137-88-2(CAS DataBase Reference)
EPA Substance Registry System
Amprolium hydrochloride (137-88-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
TJ7565000
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
31592
Product name
Amprolium hydrochloride
Purity
cationic
Packaging
250mg
Price
$52.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1034002
Product name
Amprolium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$261.6
Updated
2024/03/01
TCI Chemical
Product number
A2572
Product name
Amprolium Hydrochloride [for Biochemical Research]
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
A2572
Product name
Amprolium Hydrochloride [for Biochemical Research]
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$70
Updated
2024/03/01
Alfa Aesar
Product number
J64782
Product name
1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium chloride
Packaging
25g
Price
$90.2
Updated
2023/06/20
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Amprolium Hydrochloride Chemical Properties,Usage,Production

Description

Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.

Chemical Properties

Crystalline powder

Uses

Coccidiostatic;Thiamine transport inhibitor

Uses

Thiamine analog coccidiostat.

Uses

1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.

Definition

MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Veterinary Drugs and Treatments

Amprolium has good activity against Eimeria tenella and E. acervulina in poultry and can be used as a therapeutic agent for these organisms. It only has marginal activity or weak activity against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in combination with other agents (e.g., ethopabate) to improve control against those organisms.
In cattle, amprolium has approval for the treatment and prevention of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the control of coccidiosis, although there are no approved products in the USA for these species.

Amprolium Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Amprolium Hydrochloride Suppliers

Americas 1 Australia 1 Brazil 2 Canada 3 China 315 Czech Republic 1 Europe 4 France 1 Germany 6 India 23 Japan 3 Malaysia 1 South Korea 1 Spain 1 Switzerland 3 The Netherlands 5 Tunisia 1 Turkey 1 United Kingdom 13 United States 35 Uruguay 1 Venezuela 1 Global 423
Carbosynth
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Melrob Ltd (part of Nordmann)
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Biokemix
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Discovery Fine Chemicals Ltd.
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Molekula Limited
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Whyte Chemicals
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Molekula Ltd
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Leancare Ltd.
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CARBONE SCIENTIFIC CO.,LTD
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MOLEKULA Ltd.
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kevinbanks@molekula.com
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ETA SCIENTIFIC Co.,Ltd
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UK GREEN SCIENTIFIC CO.,LIMITED
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Eurolabs Limited
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View Lastest Price from Amprolium Hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Amprolium Hydrochloride 137-88-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
97%-101%;USP
Supply Ability
1000 KG
Release date
2021-06-03
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Amprolium HCl 137-88-2
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-27
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Amprolium HCl 137-88-2
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-27

137-88-2, Amprolium HydrochlorideRelated Search:

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  • Aminopropyl hydrochloride
  • CB2101848
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  • 137-88-2
  • C14H19N4HClCl
  • C14H19N4ClHCl
  • C14H20Cl2N4
  • C14H19CIN4
  • C14H19CIN4xHCL
  • C14H19ClN4HCl
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  • Detergents
  • API
  • Antiparasitic