ChemicalBook > CAS DataBase List > (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name
(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.
885280-38-6
Chemical Name
(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
3-(Boc-aMino)cyclohexanone;3-N-BOC-AMINO CYCLOHEXANONE;3-(Boc-amino)cyclohexanone,95%;TERT-BUTYL 3-OXOCYCLOHEXYLCARBAMATE;tert-butyl N-(3-oxocyclohexyl)carbaMate;3-Aminocyclohexan-1-one, N-BOC protected;(3-Oxo-cyclohexyl)-carbaMic acid benzyl ester;2-Methyl-2-propanyl (3-oxocyclohexyl)carbamate;(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, (3-oxocyclohexyl)-, 1,1-dimethylethyl ester
CBNumber
CB2102577
Molecular Formula
C11H19NO3
Formula Weight
213.27
MOL File
885280-38-6.mol
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(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:
81-85oC
Boiling point:
335.9±31.0 °C(Predicted)
Density 
1.06±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.01±0.20(Predicted)
form 
Solid
color 
Pale Beige
InChI
InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-8-5-4-6-9(13)7-8/h8H,4-7H2,1-3H3,(H,12,14)
InChIKey
VGDCXKATFLOEHF-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1CCCC(=O)C1
CAS DataBase Reference
885280-38-6
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Safety

HS Code 
2922390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Usbiological
Product number
265715
Product name
3-N-Boc-aminocyclohexanone
Packaging
500mg
Price
$347
Updated
2021/12/16
TRC
Product number
O849850
Product name
(3-Oxocyclohexyl)carbamicAcidtert-ButylEster
Packaging
1g
Price
$140
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
35878
Product name
tert-Butyl(3-oxocyclohexyl)carbamate
Purity
95+%
Packaging
1g
Price
$360
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50995
Product name
3-N-Boc-aminocyclohexanone
Packaging
2g
Price
$208
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50995
Product name
3-N-Boc-aminocyclohexanone
Packaging
5G
Price
$325
Updated
2021/12/16
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(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

(3-Oxocyclohexyl)carbamic Acid tert-Butyl Ester is used to prepare (benzyloxy)benzamides as TRPM8 antagonists.

Synthesis

610302-03-9

885280-38-6

General procedure for the synthesis of N-Boc-3-cyclohexanone amine from tert-butyl 3-hydroxycyclohexylcarbamate: To a solution of tert-butyl (3-hydroxycyclohexyl)carbamate (4.40 g, 20.46 mmol) in dichloromethane (DCM, 250 mL) was added Dess-Martin periodinane (13.0 g, 30.70 mmol). The reaction mixture was cooled in an ice bath and then stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with DCM and washed with aqueous sodium carbonate. The organic layer was separated and dried with anhydrous sodium sulfate and subsequently concentrated. The crude product was purified by silica gel column chromatography (eluent: 40% petroleum ether solution of ethyl acetate) to afford N-Boc-3-cyclohexanone amine (4.0 g, 18.78 mmol, 91% yield). Mass spectrum (ESI) m/z 214.1 [M + H]+.

References

[1] Patent: US2015/175557, 2015, A1. Location in patent: Paragraph 0383
[2] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 736

(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Sach biotech Co.,Ltd
Product
3-N-Boc-aminocyclohexanone 885280-38-6
Price
US $570.00-500.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5mt
Release date
2025-06-08
Career Henan Chemical Co
Product
(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER 885280-38-6
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-08-09

885280-38-6, (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

benzyl N-(3,3-difluorocyclohexyl)carbaMate 1-BOC-4-CBZ-AMINO-PIPERIDINE 1-Boc-5-hydroxyindole Tert-butyl pyrazolo[1,5-a]pyriMidin-3-ylcarbaMate T-butyl-3-oxocyclobutanecarboxylate N-Boc-4-(Cyclopropylmethyl)piperazine TERT-BUTYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) N-Boc-2-aminoacetaldehyde N-(BOC)-6-fluoro-indole N-BOC-7-BENZYL-2,7-DIAZASPIRO[3.5]NONANE N-Boc-N,N-bis(2-bromoethyl)amine tert-butyl N-[(2-chloropyridin-4-yl)Methyl]carbaMate TERT-BUTYL 4-IODOBUTYLCARBAMATE Carbamic acid, (3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, 4-pentenyl-, 1,1-dimethylethyl ester (9CI) Hydrazinecarboxylic acid, 1-(2-propenyl)-, 1,1-diMethylethyl ester tert-butyl 5-aminopentanoate

  • TERT-BUTYL 3-OXOCYCLOHEXYLCARBAMATE
  • (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
  • 3-N-BOC-AMINO CYCLOHEXANONE
  • tert-butyl N-(3-oxocyclohexyl)carbaMate
  • 3-(Boc-aMino)cyclohexanone
  • Carbamic acid, (3-oxocyclohexyl)-, 1,1-dimethylethyl ester
  • (3-Oxo-cyclohexyl)-carbaMic acid benzyl ester
  • 3-Aminocyclohexan-1-one, N-BOC protected
  • tert-Butyl (3-oxocyclohexyl)carbamate, 1-[(tert-Butoxycarbonyl)amino]-3-oxocyclohexane
  • Carbamic acid,N-(3-oxocyclohexyl)-, 1,1-dimethylethyl ester
  • 3-(Boc-amino)cyclohexanone,95%
  • 2-Methyl-2-propanyl (3-oxocyclohexyl)carbamate
  • 885280-38-6