N-Boc-2-aminoacetaldehyde

Product Name: N-Boc-2-aminoacetaldehyde
CAS No.: 89711-08-0
Chemical Name: N-Boc-2-aminoacetaldehyde
Synonyms: tert-butyl 2-oxoethylcarbaMate;N-(t-butoxycarbonyl)glycinal;TERT-BUTYL N-(2-OXOETHYL)CARBAMATE;(2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;EOS-61204;2-Boc-Aminoacetaldehyde;n-boc-2-aminoacetaldehyde;N-Boc-2-aMinoacetaldehyde 95%;t-butyl-(2-oxoethyl)carbamate;T-BUTYL N-(2-OXOETHYL)CABAMATE
CBNumber: CB6359315
Molecular Formula: C7H13NO3
Formula Weight: 159.18
MOL File: 89711-08-0.mol

More

Less

N-Boc-2-aminoacetaldehyde Property

Boiling point:: 237.2±23.0 °C(Predicted)
Density: 1.035±0.06 g/cm3(Predicted)
refractive index: n20/D 1.455(lit.)
Flash point:: >230 °F
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 11.35±0.46(Predicted)
form: Solid
color: Colourless to Light Yellow Gel
Stability:: Hygroscopic, Temperature Sensitive
InChI: InChI=1S/C7H13NO3/c1-7(2,3)11-6(10)8-4-5-9/h5H,4H2,1-3H3,(H,8,10)
InChIKey: ACNRTYKOPZDRCO-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCC=O

More

Less

Safety

WGK Germany: 3
HS Code: 2924297099

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 472654
Product name: N-Boc-2-aminoacetaldehyde
Purity: 95%
Packaging: 1g
Price: $96.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 472654
Product name: N-Boc-2-aminoacetaldehyde
Purity: 95%
Packaging: 5g
Price: $250
Updated: 2025/07/31

Sigma-Aldrich

Product number: 472654
Product name: N-Boc-2-aminoacetaldehyde
Purity: 95%
Packaging: 25g
Price: $720
Updated: 2025/07/31

Usbiological

Product number: 165348
Product name: N-Boc-2-aminoacetaldehyde
Packaging: 2.5g
Price: $425
Updated: 2021/12/16

TRC

Product number: B600600
Product name: N-Boc-2-aminoacetaldehyde
Packaging: 25g
Price: $430
Updated: 2021/12/16

More

Less

N-Boc-2-aminoacetaldehyde Chemical Properties,Usage,Production

Chemical Properties

A highly reactive aldehyde and amide structure in the structure of N-tert-butoxycarbonyl-2-aminoacetaldehyde can be involved in a variety of organic synthetic transformation reactions, for example, the aldehyde unit in the structure can be condensed with amines to obtain the corresponding imine compounds.

Uses

A building block in the synthesis of a protected pyrroloproline.

Uses

N-Boc-2-aMinoacetaldehyde can be also used in a three-component synthesis of pyrrolidines involving 1,3-dipolar cycloaddition.

Uses

N-Boc-2-aminoacetaldehyde is used in the synthesis of carbohydrates as well as studies relating to inhibitors of cathepsin K.

General Description

N-Boc-2-aminoacetaldehyde is an organic building block. It reacts with Horner-Wadsworth-Emmons (HWE) reagent to afford γ-aminobutyric acid (GABA)-derived α-keto amide/ester units.

Synthesis

121505-93-9

89711-08-0

The general procedure for the synthesis of N-tert-butoxycarbonyl-2-aminoacetaldehyde from N-BOC-gly-N'-methoxy-N'-methylamide was as follows: under argon protection, Boc-Gly-N-methoxy-N-methylamide (19) (4.37 g, 20 mmol) was dissolved in 150 mL of anhydrous THF and stirred in an ice-water bath for 30 min. An ether solution of LAH (1 M, 30 mL, 30 mmol) was slowly added to the above well-stirred solution through a cannula under argon protection. The reaction solution continued to be stirred for 30 minutes. Subsequently, aqueous potassium bisulfate solution (4.77 g, 35 mmol dissolved in 60 mL of water) was slowly added to the reaction solution and stirred for 10 minutes. The organic solvent was removed by evaporation under reduced pressure. To the remaining aqueous phase, 60 mL of water was added and then extracted with dichloromethane (DCM, 100 mL x 4). The DCM extracts were combined and washed sequentially with 1 M hydrochloric acid solution (100 mL x 4), saturated sodium bicarbonate solution (100 mL x 2), and saturated sodium chloride solution (100 mL), dried overnight with 4 g of anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure to give light yellow oil 20 (2.83 g), which could be used in the next reaction without further purification. Yield: 89%. Thin layer chromatography (TLC) Rf = 0.44 (Expanding agent: hexane-ethyl acetate = 1:1). 1H-NMR (90 MHz, CDCl3) δppm: 9.60 (s, 1H), 5.26 (s, br, 1H), 4.04 (d, 2H, J = 5.1 Hz), 1.46 (s, 9H).

References

[1] Nucleosides, Nucleotides and Nucleic Acids, 2001, vol. 20, # 4-7, p. 1393 - 1397
[2] Patent: US2006/161007, 2006, A1. Location in patent: Page/Page column 3; 8-9; Sheet 1
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 1, p. 65 - 77
[4] Tetrahedron, 2001, vol. 57, # 23, p. 4903 - 4923
[5] European Journal of Medicinal Chemistry, 1991, vol. 26, # 9, p. 921 - 928

N-Boc-2-aminoacetaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Boc-2-aminoacetaldehyde Suppliers

Canada 1 China 161 Europe 1 India 2 Switzerland 1 United Kingdom 3 United States 18 Global 187

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375892 15553111391
Email: 3276840968@qq.com
Country: China
ProdList: 301
Advantage: 58

Yancheng Shunde Chemical Technology Co., Ltd.

Tel: 13661532809; 13813431578
Email: tianleyu@163.com
Country: China
ProdList: 80
Advantage: 58

Shanghai G&K Biomedical Scientific Inc.

Tel: 021-34502253 13391330186
Fax: +86-21-23027826
Email: info@gksci.com
Country: China
ProdList: 133
Advantage: 52

Shanghai Kaimo Pharmaceutical Co., Ltd.

Tel: 021-50521023 18019779209
Fax: QQ2522822918
Email: sales@kaimopharm.com
Country: China
ProdList: 227
Advantage: 58

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Anhui Qiushi Medical Technology Co., Ltd

Tel: 15005516438
Fax: 15005516438
Email: sales1@qiushipharm.com
Country: China
ProdList: 82
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

More

Less

View Lastest Price from N-Boc-2-aminoacetaldehyde manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: N-Boc-2-aminoacetaldehyde 89711-08-0
Price: US $15.00-50.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 5 ton per month
Release date: 2023-09-21

Career Henan Chemical Co

Product: T-BUTYL N-(2-OXOETHYL)CABAMATE 89711-08-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

89711-08-0, N-Boc-2-aminoacetaldehydeRelated Search:

BOC-ABU-OH BOC-Glycine BOC-L-NORLEUCINE Boc-O-(2-bromo-Cbz)-L-Tyrosine N-(tert-Butoxycarbonyl)-L-alanine BOC-LYS(TFA)-OH BOC-N-Methyl-L-alanine BOC-MET(O)-OH N-(tert-Butoxycarbonyl)-L-phenylalanine BOC-NVA-OH BOC-L-Tyrosine BOC-L-Serine BOC-TRP-OSU BOC-4-IODO-L-PHENYLALANINE BOC-O-BENZYL-L-TYROSINE 4-NITROPHENYL ESTER BOC-D-TYR(2,6-DI-CL-BZL)-OH BOC-ILE-OSU BOC-TRP-ONP

(2-OXO-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

TERT-BUTYL N-(2-OXOETHYL)CARBAMATE

T-BUTYL N-(2-OXOETHYL)CABAMATE

Carbamic acid, (2-oxoethyl)-, 1,1-dimethylethyl ester (9CI)

n-boc-2-aminoacetaldehyde

Tert-Butyl-N-(2-oxo ethyl)cabaMate

N-Boc-2-aminoacetaldehyde,tert-Butyl N-(2-oxoethyl)carbamate

tert-butyl 2-oxoethylcarbaMate

CarbaMic acid,N-(2-oxoethyl)-, 1,1-diMethylethyl ester

N-Boc-2-aMinoacetaldehyde 95%

N-(2-OXOETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

EOS-61204

N-(t-butoxycarbonyl)glycinal

t-butyl-(2-oxoethyl)carbamate

N-tert-butyloxycarbonyl-2-aminoacetaldehyde

N-tert-butoxycarbonyl-2-aminoacetaldehyde

2-Methyl-2-propanyl (2-oxoethyl)carbamate

2-Boc-Aminoacetaldehyde

<i>N</i>-Boc-2-aminoacetaldehyde

89711-08-0

HCOCH2NHCO2CCH33

Aldehydes

Building Blocks

Carbonyl Compounds

C7

Organic Building Blocks

Aldehydes

B

Bioactive Small Molecules

Building Blocks

C7

Carbonyl Compounds

Cell Biology

Chemical Synthesis

Organic Building Blocks

N-BOC

pharmacetical