BOC-Glycine

Product Name: BOC-Glycine
CAS No.: 4530-20-5
Chemical Name: BOC-Glycine
Synonyms: BOC-GLY-OH;BOC-GLY;N-(TERT-BUTOXYCARBONYL)GLYCINE;N-BOC-GLYCINE;BOC-L-GLY-OH;BOC-GLYCINE-OH;Boc-g;Boc-glycin;TBOC-GLYCINE;GLYCINE-N-T-BOC
CBNumber: CB8187260
Molecular Formula: C7H13NO4
Formula Weight: 175.18
MOL File: 4530-20-5.mol

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BOC-Glycine Property

Melting point:: 86-89 °C(lit.)
Boiling point:: 306.47°C (rough estimate)
Density: 1.2843 (rough estimate)
refractive index: 1.4353 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 4.00±0.10(Predicted)
color: White to off-white
Water Solubility: soluble
BRN: 1101514
Major Application: peptide synthesis
InChI: InChI=1S/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)
InChIKey: VRPJIFMKZZEXLR-UHFFFAOYSA-N
SMILES: C(O)(=O)CNC(OC(C)(C)C)=O
CAS DataBase Reference: 4530-20-5(CAS DataBase Reference)
EPA Substance Registry System: Glycine, N-[(1,1-dimethylethoxy)carbonyl]- (4530-20-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-41-36/37/38-20/21/22
Safety Statements: 26-36/37/39-39-36
RIDADR: UN2811
WGK Germany: 3
TSCA: TSCA listed
HazardClass: 6.1
HS Code: 29241990
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H318Causes serious eye damage

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53000
Product name: Boc-Gly-OH
Purity: Novabiochem?
Packaging: 25G
Price: $61.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53000
Product name: Boc-Gly-OH
Purity: Novabiochem?
Packaging: 100G
Price: $127
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53000
Product name: Boc-Gly-OH
Purity: Novabiochem®
Packaging: 1 kg
Price: $860
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53000
Product name: Boc-Gly-OH
Purity: Novabiochem®
Packaging: 1 kg
Price: $860
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15420
Product name: Boc-Gly-OH
Purity: ≥99.0% (T)
Packaging: 5g
Price: $33.5
Updated: 2025/07/31

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BOC-Glycine Chemical Properties,Usage,Production

Chemical Properties

White To Off-White Powder

Uses

Boc-Gly-OH can be used:

For the esterification reaction to synthesize N-Boc amino acid esters for peptide chemistry.
For the synthesis of tripeptide H-Gly-Pro-Glu-OH, analogs of neuroprotective drugs.
As a promoter for the allylation of hydrazones and isatin.

Uses

BOC-Glycine is used in the composition of drugs containing Ketoprofen, and Sodium hyaluronate as antiinflammatory agents.

Synthesis Reference(s)

Tetrahedron Letters, 16, p. 4393, 1975 DOI: 10.1016/S0040-4039(00)91133-X

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

1. 18.1g L-glycine, 100ml water was added to the reaction flask and stirred. Add 16g of sodium hydroxide configured 0.01mol/L alkaline solution adjusted to alkaline. Then 8g of (Boc)2O was added and reacted for 2 hours, then 8g of (Boc)2O was added and reacted for 2 hours and finally 9g of (Boc)2O was added and reacted for 4 hours.

2. The impurities were extracted three times with hexane 12 ml/time. 3 mol/L hydrochloric acid was used to adjust the PH=3 and then the product was extracted three times with dioxane 0.6 L/time. Combine the ester layers and wash with brine to neutral. Add 15 g of anhydrous sodium sulfate to dry for 10 hours.

3. Filter, concentrate the filtrate dry under reduced pressure, add 60 ml of hexane and stir to crystallize. Centrifuged out the product and dried. Obtained product 25.0 g. Yield 93.87%.

BOC-Glycine Preparation Products And Raw materials

Raw materials

Glycine 1,4-Dioxane Ethyl acetate

Preparation Products

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BOC-Glycine Suppliers

Americas 1 Belgium 1 Canada 3 China 519 Europe 4 France 4 Germany 9 Hungary 1 India 60 Italy 1 Japan 8 Poland 1 Russia 1 South Korea 1 Switzerland 7 The Netherlands 1 Ukraine 1 United Kingdom 15 United States 69 Global 707

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
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GenChem & GenPharm (Changzhou) Co., Ltd.

Tel: 0519-85720003 18861157602
Fax: 0519-85720007
Email: 410649415@qq.com
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Hubei Hengluyuan Technology Co., Ltd.

Tel: 027-027-88188016 18062414339
Fax: +86-02788188026
Email: 1764683941@qq.com
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Shanghai Chiral Chemicals Inc.

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Hubei Soren Technology Co., Ltd

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Country: China
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Zhangjiagang Specom Biochemical Co., Ltd.

Tel: 512-0512-58992291,58992287 18606280718
Email: admin@spbiochem.com
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
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INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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View Lastest Price from BOC-Glycine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: BOC-Glycine 4530-20-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-03

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-gly 4530-20-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98+
Supply Ability: 1T
Release date: 2023-11-27

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Boc-Glycine 4530-20-5
Price: US $75.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-07

4530-20-5, BOC-GlycineRelated Search:

N-(tert-Butoxycarbonyl)-L-phenylalanine Boc-Aib-OH N-Carbobenzyloxyglycine 4-Aminophenylacetic acid 4-Hydroxy-D-(-)-2-phenylglycine Betaine Boc-D-Glutamine BOC-PRO-PRO-OH BOC-CYS(4-MEOBZL)-OH BOC-N-ETHYL GLYCINE Glycine tert-Butanol BOC-GLY-LEU-OH BOC-N-Methyl-L-alanine BOC-NVA-OH BOC-L-Tyrosine BOC-L-Serine N-(tert-Butoxycarbonyl)-L-alanine

BOC-Glycine, 99+%

Boc-glycin

N-tert-Boc-glycine-OH

BOC-GLYCINE(N-TERT-BUTOXYCARBONYLGLYCINE)

n-[(1,1-dimethylethoxy)carbonyl]-glycin

glycine(sterile)

N-ALPHA-T-BUTYLOXYCARBONYL-GLYCINE

BOC-L-GLY-OH

N-(tert-Butoxycarbonyl)glycine, Boc-glycine

2-[(2-Methylpropan-2-yl)oxycarbonylamino]acetic acid

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-

[(tert-Butyloxycarbonyl)amino]acetic acid

N-(tert-Butyloxycarbonyl)glycine

[(t-Butoxycarbonyl)amino]acetic acid 97+%

[(t-Butoxycarbonyl)amino]acetic acid

BOC-GLYCINE-OH

BOC-GLY

BOC-GLYCINE

BOC-GLY-OH

BOC-L-GLY

BOC-AMINOXYACETIC ACID

N-T-BOC-GLYCINE

N-T-BUTOXYCARBONYL-GLYCINE

N-(TERT-BUTOXYCARBONYL)GLYCINE

N-ALPHA-T-BOC-GLYCINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-GLYCINE

N-BOC-GLYCINE

N-BOC-L-GLYCINE

T-BUTYLOXYCARBONYLGLYCINE

TBOC-GLYCINE

RARECHEM AL BO 1404

Boc-Gly-OH~N-(tert-Butoxycarbonyl)glycine

N-tert-Butoxycarbonylglycine, 98+%

N-Boc-glycine,98+%

2-tert-Butoxycarbonylaminoacetic acid

N-[(1,1-Dimethylethoxy)carbonyl]-glycine

N-[(1,1-DiMethylethoxy) carbonyl]gl

N-carboxyglycine N-tert-Butyl Ester

N-Boc-glycine Boc-Gly-OH

GLYCINE-N-T-BOC

N-tert-Butoxycarbonylglycine ,99%

BOC-Glycine, 99+% 10GR

Boc-Gly-OH >=99.0% (T)

Boc-Glycine Synonyms N-(tert-Butoxycarbonyl)glycine

N-BOC-Gly-OH

N-(tert-Butoxycarbonyl)glycine

Butoxycarbonyl Glycine

tert.-Butoxycarbonyl Glycine

(Tert-Butoxy)Carbonyl Gly-OH

Glycine, N-carboxy-, N-tert-butyl ester

t-Butoxycarbonylglycine

Boc-glycine≥ 98.5% (HPLC)

Boc-g

y-OH

N-(tert-Butoxycarbonyl)glycine &gt

Boc-GL

BOC-Glycine USP/EP/BP

Tert-butoxycarbonylglycine USP/EP/BP