BOC-N-ETHYL GLYCINE
- Product Name
- BOC-N-ETHYL GLYCINE
- CAS No.
- 149794-10-5
- Chemical Name
- BOC-N-ETHYL GLYCINE
- Synonyms
- Boc-N-EtGly-OH;BOC-N-ETHYLGLY-OH;BOC-N-ETHYL GLYCINE;N-BOC-N-ETHYL-GLYCINE;N-Boc-N-ethylglycine,97%;BOC-N-ETHYL GLYCINE USP/EP/BP;Boc-N-ethyl glycine≥ 98% (HPLC);N-Ethylglycine, N-BOC protected;N-(tert-Butoxycarbonyl)-N-ethylglycine;2-(tert-butoxycarbonyl(ethyl)amino)acetic acid
- CBNumber
- CB8242868
- Molecular Formula
- C9H17NO4
- Formula Weight
- 203.24
- MOL File
- 149794-10-5.mol
BOC-N-ETHYL GLYCINE Property
- Melting point:
- 87-88℃
- Boiling point:
- 302.7±21.0 °C(Predicted)
- Density
- 1.113±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 4.03±0.10(Predicted)
- form
- lumpy crystalline powder
- color
- Off white to faint lemon
- InChI
- InChI=1S/C9H17NO4/c1-5-10(6-7(11)12)8(13)14-9(2,3)4/h5-6H2,1-4H3,(H,11,12)
- InChIKey
- SPBIXXXFDSLALC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CN(C(OC(C)(C)C)=O)CC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B655005
- Product name
- N-Boc-N-ethyl-glycine
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- OR20016
- Product name
- N-Ethylglycine,N-BOCprotected
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4158-1-58
- Product name
- N-Ethylglycine, N-Boc protected
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- AS85006
- Product name
- N-Boc-N-ethyl-glycine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 05080
- Product name
- Boc--ethyl glycine
- Purity
- ≥ 98% (HPLC)
- Packaging
- 1G
- Price
- $30
- Updated
- 2021/12/16
BOC-N-ETHYL GLYCINE Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
N-Boc-N-ethyl Glycine, is a substituted Glycine (G615990) used as a building block for the synthesis of more complex pharmaceutical compounds. It can be used for designing potent, selective, orally active, peptide-based fibrinogen receptor antagonists.
Synthesis
4530-20-5
75-03-6
149794-10-5
General procedure for the synthesis of 2-((tert-butoxycarbonyl)(ethyl)amino)acetic acid from BOC-glycine and iodoethane: Following the method of Grigg et al [Blaney, P.; Grigg, R.; Rankovic, Z.; Thornton-Pett, M.; Xu, J. Tetrahedron, 2002, 58,. 1719-1737], sodium hydride (480 mg, 60% oil dispersion, 12.0 mmol, 4.0 eq.) was added to a round-bottom flask and purged with nitrogen for 15 min. THF (6.0 mL) was added to the flask and the suspension was cooled to 0 °C using an ice water bath. In another flask, BOC-glycine (525 mg, 3.0 mmol), anhydrous THF (6.0 mL), and ethidium iodide (1.0 mL, 12 mmol, 4 eq.) were mixed. The mixture was added dropwise to the cooled NaH suspension, kept at 0 °C and stirred vigorously. After 1 hour of reaction, the mixture was warmed to room temperature and stirring was continued overnight. The reaction mixture was cooled again to 0 °C and methanol (4 mL) was added slowly to quench the excess sodium hydride. The reaction mixture was diluted by adding deionized water and methanol was removed under reduced pressure. The impurities were extracted with a 90% ethyl acetate-hexane solvent mixture and the pH of the aqueous layer was subsequently adjusted to 2-3 by addition of solid citric acid. the product was again extracted with a 90% ethyl acetate-hexane solvent mixture. The organic layers were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the target product 2-((tert-butoxycarbonyl)(ethyl)amino)acetic acid in quantitative yield.
References
[1] Patent: WO2006/69063, 2006, A1. Location in patent: Page/Page column 132-133
[2] Patent: WO2007/106192, 2007, A2. Location in patent: Page/Page column 70; 71
[3] Patent: WO2008/79735, 2008, A1. Location in patent: Page/Page column 45
[4] Patent: WO2008/134679, 2008, A1. Location in patent: Page/Page column 94
[5] Journal of the American Chemical Society, 1993, vol. 115, # 10, p. 4228 - 4245
BOC-N-ETHYL GLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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