ChemicalBook > CAS DataBase List > BOC-N-ETHYL GLYCINE

BOC-N-ETHYL GLYCINE

Product Name: BOC-N-ETHYL GLYCINE
CAS No.: 149794-10-5
Chemical Name: BOC-N-ETHYL GLYCINE
Synonyms: Boc-N-EtGly-OH;BOC-N-ETHYLGLY-OH;BOC-N-ETHYL GLYCINE;N-BOC-N-ETHYL-GLYCINE;N-Boc-N-ethylglycine,97%;BOC-N-ETHYL GLYCINE USP/EP/BP;Boc-N-ethyl glycine≥ 98% (HPLC);N-Ethylglycine, N-BOC protected;N-(tert-Butoxycarbonyl)-N-ethylglycine;2-(tert-butoxycarbonyl(ethyl)amino)acetic acid
CBNumber: CB8242868
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 149794-10-5.mol

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BOC-N-ETHYL GLYCINE Property

Melting point:: 87-88℃
Boiling point:: 302.7±21.0 °C(Predicted)
Density: 1.113±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.03±0.10(Predicted)
form: lumpy crystalline powder
color: Off white to faint lemon
InChI: InChI=1S/C9H17NO4/c1-5-10(6-7(11)12)8(13)14-9(2,3)4/h5-6H2,1-4H3,(H,11,12)
InChIKey: SPBIXXXFDSLALC-UHFFFAOYSA-N
SMILES: C(O)(=O)CN(C(OC(C)(C)C)=O)CC

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B655005
Product name: N-Boc-N-ethyl-glycine
Packaging: 1g
Price: $165
Updated: 2021/12/16

Apolloscientific

Product number: OR20016
Product name: N-Ethylglycine,N-BOCprotected
Packaging: 1g
Price: $22
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4158-1-58
Product name: N-Ethylglycine, N-Boc protected
Packaging: 1g
Price: $28
Updated: 2021/12/16

Activate Scientific

Product number: AS85006
Product name: N-Boc-N-ethyl-glycine
Purity: 95+%
Packaging: 1g
Price: $29
Updated: 2021/12/16

Chem-Impex

Product number: 05080
Product name: Boc--ethyl glycine
Purity: ≥ 98% (HPLC)
Packaging: 1G
Price: $30
Updated: 2021/12/16

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BOC-N-ETHYL GLYCINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-N-ethyl Glycine, is a substituted Glycine (G615990) used as a building block for the synthesis of more complex pharmaceutical compounds. It can be used for designing potent, selective, orally active, peptide-based fibrinogen receptor antagonists.

Synthesis

4530-20-5

75-03-6

149794-10-5

General procedure for the synthesis of 2-((tert-butoxycarbonyl)(ethyl)amino)acetic acid from BOC-glycine and iodoethane: Following the method of Grigg et al [Blaney, P.; Grigg, R.; Rankovic, Z.; Thornton-Pett, M.; Xu, J. Tetrahedron, 2002, 58,. 1719-1737], sodium hydride (480 mg, 60% oil dispersion, 12.0 mmol, 4.0 eq.) was added to a round-bottom flask and purged with nitrogen for 15 min. THF (6.0 mL) was added to the flask and the suspension was cooled to 0 °C using an ice water bath. In another flask, BOC-glycine (525 mg, 3.0 mmol), anhydrous THF (6.0 mL), and ethidium iodide (1.0 mL, 12 mmol, 4 eq.) were mixed. The mixture was added dropwise to the cooled NaH suspension, kept at 0 °C and stirred vigorously. After 1 hour of reaction, the mixture was warmed to room temperature and stirring was continued overnight. The reaction mixture was cooled again to 0 °C and methanol (4 mL) was added slowly to quench the excess sodium hydride. The reaction mixture was diluted by adding deionized water and methanol was removed under reduced pressure. The impurities were extracted with a 90% ethyl acetate-hexane solvent mixture and the pH of the aqueous layer was subsequently adjusted to 2-3 by addition of solid citric acid. the product was again extracted with a 90% ethyl acetate-hexane solvent mixture. The organic layers were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the target product 2-((tert-butoxycarbonyl)(ethyl)amino)acetic acid in quantitative yield.

References

[1] Patent: WO2006/69063, 2006, A1. Location in patent: Page/Page column 132-133
[2] Patent: WO2007/106192, 2007, A2. Location in patent: Page/Page column 70; 71
[3] Patent: WO2008/79735, 2008, A1. Location in patent: Page/Page column 45
[4] Patent: WO2008/134679, 2008, A1. Location in patent: Page/Page column 94
[5] Journal of the American Chemical Society, 1993, vol. 115, # 10, p. 4228 - 4245

BOC-N-ETHYL GLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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149794-10-5, BOC-N-ETHYL GLYCINERelated Search:

BOC-PRO-PRO-OH BOC-CYS(4-MEOBZL)-OH BOC-Glycine BOC-PRO-OSU BOC-3,4-DEHYDRO-PRO-OH BOC-D-PRO-OME tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate BOC-HYP(BZL)-OH tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Boc-Hyp-OH BOC-L-Proline (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-PRO-OSU N-Boc-trans-4-Hydroxy-L-proline methyl ester (S)-1-Boc-piperidine-2-carboxylic acid Glycine BOC-PYR-OH DCHA BOC-D-TIC-OH

N-BOC-N-ETHYL-GLYCINE

BOC-N-ETHYL GLYCINE

BOC-N-ETHYLGLY-OH

N-(tert-Butoxycarbonyl)-N-ethylglycine

2-(tert-butoxycarbonyl(ethyl)amino)acetic acid

Boc-N-ethyl glycine≥ 98% (HPLC)

2-[ethyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetic acid

Boc-N-EtGly-OH

N-Ethylglycine, N-BOC protected

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-ethyl-

N-Boc-N-ethylglycine,97%

BOC-N-ETHYL GLYCINE USP/EP/BP

149794-10-5

Amino Acid Derivatives

Amino Acids