BOC-N-Methyl-L-alanine

Product Name: BOC-N-Methyl-L-alanine
CAS No.: 16948-16-6
Chemical Name: BOC-N-Methyl-L-alanine
Synonyms: BOC-N-ME-ALA-OH;Boc-N-Me-Ala;BOC-MEALA-OH;Boc-Lys(TFA);N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ALANINE;N-[(1,1-DiMethylethoxy)carbonyl]-N-Methyl-L-alanine;Boc-NaL;BOC-L-MEALA-OH;BOC-N-ME-ALANINE;BOC-N-ME-S-ALA-OH
CBNumber: CB7133215
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 16948-16-6.mol

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BOC-N-Methyl-L-alanine Property

Melting point:: 88-92 °C
Boiling point:: 296.3±19.0 °C(Predicted)
Density: 1.111±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 4.03±0.10(Predicted)
color: White
optical activity: [α]20/D 30±1°, c = 1% in ethanol
BRN: 2366513
InChI: InChI=1S/C9H17NO4/c1-6(7(11)12)10(5)8(13)14-9(2,3)4/h6H,1-5H3,(H,11,12)/t6-/m0/s1
InChIKey: VLHQXRIIQSTJCQ-LURJTMIESA-N
SMILES: C(O)(=O)[C@H](C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference: 16948-16-6(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 2924 19 00
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53082
Product name: Boc-N-Me-Ala-OH
Purity: Novabiochem?
Packaging: 5G
Price: $403
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15549
Product name: Boc-N-Me-Ala-OH
Purity: ≥99.0% (TLC)
Packaging: 1g
Price: $87.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15549
Product name: Boc-N-Me-Ala-OH
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $309
Updated: 2024/03/01

TCI Chemical

Product number: B3651
Product name: N-(tert-Butoxycarbonyl)-N-methyl-L-alanine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B3651
Product name: N-(tert-Butoxycarbonyl)-N-methyl-L-alanine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $94
Updated: 2025/07/31

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BOC-N-Methyl-L-alanine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-N-methyl-L-alanine can be used in peptide synthesis.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

15761-38-3

74-88-4

16948-16-6

General method: (S)-2-(tert-butoxycarbonylamino)-3-hydroxypropanoic acid (1 eq.) and iodomethane (10 eq.) were dissolved in anhydrous THF under nitrogen protection and cooled to 0 °C. Pure sodium hydride (10 eq.) was added in batches over 2.0 h. The reaction mixture was kept stirred at 0°C. Subsequently, the reaction mixture was continued to be stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was diluted with ether (20 mL) and quenched with water (30 mL). The organic layer was separated and the aqueous layer was extracted with ether (2 x 15 mL). The combined organic layers were adjusted to pH 3 with aqueous citric acid and then extracted with EtOAc (3 x 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4 and concentrated under reduced pressure to give BOC-N-methyl-L-alanine in 90% yield as a colorless oil.

References

[1] Tetrahedron, 2006, vol. 62, # 2-3, p. 264 - 284
[2] Chemistry - A European Journal, 2013, vol. 19, # 32, p. 10619 - 10624
[3] British Journal of Pharmacology, 2016, p. 2657 - 2668
[4] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1148 - 1162
[5] Canadian Journal of Chemistry, 1977, vol. 55, p. 906 - 910

BOC-N-Methyl-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-N-Methyl-L-alanine Suppliers

Americas 1 Canada 1 China 285 Europe 3 France 1 Germany 5 India 9 Japan 5 South Korea 1 Switzerland 4 United Kingdom 10 United States 42 Global 367

Lavem Chine Pharm Company

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Energy Chemical

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View Lastest Price from BOC-N-Methyl-L-alanine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: BOC-N-Methyl-L-alanine 16948-16-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Hangzhou ICH Biofarm Co., Ltd

Product: Boc-N-methyl-L-alanine 16948-16-6
Price: US $0.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-26

Career Henan Chemical Co

Product: BOC-N-Methyl-L-alanine 16948-16-6
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

16948-16-6, BOC-N-Methyl-L-alanineRelated Search:

Phenprobamate N-Methyl-L-alanine L-Alanine Bensulfuron methyl D-Alanine Kresoxim-methyl N-(tert-Butoxycarbonyl)-L-alanine Methyl salicylate EC 2.6.1.2 Boc-Aib-OH tert-Butyldimethylsilyl chloride TRIMETHYLPHOSPHINE OXIDE N-Boc-L-valine METSULFURON METHYL Methylparaben Fmoc-Lys(Boc)-OH Thiophanate-methyl BOC-L-Serine

BOC-L-MEALA-OH

BOC-N-ALPHA-METHYL-L-ALANINE

BOC-MEALA-OH

BOC-N-ME-ALANINE

BOC-N-ME-ALA-OH

BOC-N-ME-S-ALA-OH

BOC-N-METHYL-L-ALANINE

BOC-N-METHYL-L-ALA-OH

N-ALPHA-T-BOC-N-ALPHA-METHYL-L-ALANINE

N-ALPHA-T-BUTYLOXYCARBONYL-N-METHYL-L-ALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ALANINE

N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ALANINE

2-(tert-Butoxycarbonyl-methyl-amino)-propionic acid

Boc-N-Me-L-Ala-Oh

Boc-N-Me-Ala-OH Boc-N-methyl-alanine

N-tert-Butoxycarbonyl-N-methyl-L-alanine

Boc-N-methyl-L-alanine ,98%

Boc-N-methyl-Alanine

N-[(1,1-DiMethylethoxy)carbonyl]-N-Methyl-L-alanine

N-Methyl- N-(tert-butyloxycarbonyl)alanine

N-tert-Butoxycarbonyl-N-Methylalanine

N-Boc-N-methyl-L-alanine Boc-N-Me-Ala-OH

N-BOC-N-METHYL-L-ALANINE

(2S)-2-[(tert-butoxycarbonyl)(Methyl)aMino]propanoic acid

(S)-2-(tert-Butoxycarbonyl-Methyl-aMino)-propionic acid

Boc-Lys(TFA)

Boc-N-Me-Ala

Boc-Nalpha-Methyl-L-alanine, 95+%

Boc-N-methyl-L-alanine≥ 99% (HPLC, Chiral purity)

(Tert-Butoxy)Carbonyl N-Me-Ala-OH

N-(tert-Butoxycarbonyl)-N-methyl-L-alanine &gt

Boc-NaL

L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-

BOC-N-Methyl-L-alanine USP/EP/BP

(2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid

Boc-N-a-methyl-L-alanine

Boc-N-α-Methyl-L-alanine

Boc-<i>N</i>-Me-Ala-OH

Anamorelin Impurity 46

16948-16-6

Specialty Synthesis

Unnatural Amino Acid Derivatives

Peptide Synthesis

N-Methyl Amino Acids

Pyrazoles

Boc-Amino acid series

Amino Acids & Derivatives

Chiral Reagents

amino acids

Alanine [Ala, A]

N-Methyl Amino Acids