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HOLO-TRANSFERRIN

Product Name
HOLO-TRANSFERRIN
CAS No.
11096-37-0
Chemical Name
HOLO-TRANSFERRIN
Synonyms
HOLO;Optiferrin;SIDEROPHILIN;transferrins;APO-TRANSFERRIN;HOLO-TRANSFERRIN;HUMAN TRASFERRIN;Holotransferrins;HUMAN TRANSFERRIN;TRANSFERRIN (APO)
CBNumber
CB2103448
Molecular Formula
C16H22N6O4
Formula Weight
362.38368
MOL File
11096-37-0.mol
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HOLO-TRANSFERRIN Property

storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
Brown to reddish brown
Water Solubility 
Soluble in water (50 mg/ml).
CAS DataBase Reference
11096-37-0
EPA Substance Registry System
Transferrin (11096-37-0)
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Safety

Hazard Codes 
B,Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
21
TSCA 
Yes
HS Code 
3002120000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3915
Product name
Transferrin-biotin labeled human
Purity
lyophilized powder containing sodium citrate
Packaging
5MG
Price
$208
Updated
2024/03/01
Sigma-Aldrich
Product number
T3705
Product name
Transferrin human
Purity
recombinant, expressed in rice
Packaging
1G
Price
$636
Updated
2024/03/01
Sigma-Aldrich
Product number
T3705
Product name
Transferrin human
Purity
recombinant, expressed in rice
Packaging
5G
Price
$2970
Updated
2024/03/01
Sigma-Aldrich
Product number
T1428
Product name
apo-Transferrin bovine
Purity
BioReagent, suitable for cell culture, ≥98%
Packaging
50MG
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
T1428
Product name
apo-Transferrin bovine
Purity
BioReagent, suitable for cell culture, ≥98%
Packaging
100MG
Price
$158
Updated
2024/03/01
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HOLO-TRANSFERRIN Chemical Properties,Usage,Production

Description

Holo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.

Uses

Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Human holo-transferrin is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media.

Uses

Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Uses

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.

Definition

ChEBI: Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.

General Description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Pharmaceutical Applications

Transferrins are a group of proteins that are abundant in blood and their primary role is to transport Fe3+, as free Fe3+ would be toxic to most organisms. Transferrin consists of a single polypeptide chain independently binding a maximum of two Fe3+ ions. Fe3+ is bound in a hexa-coordinated high-spin complex within the protein. The metal is coordinated by the N atom from the imidazole residue, two deprotonated phenol groups, a carboxylate and a carbonato ligand.

Biochem/physiol Actions

Studies have shown that co-treatment of breast cancer cells with holo-transferrin, which increases iron levels within cells and derivatives of artemisinin results in increased cell death.

Purification Methods

This transferrin is purified by affinity chromatography on phenyl-boronate agarose followed by DEAE-Sephacel chromatography. The product is free from haemopexin. [Cook et al. Anal Biochem 149 349 1985, Aisen & Listowsky Ann Rev Biochem 49 357 1980.]

References

https://en.wikipedia.org/wiki/Transferrin
http://www.prospecbio.com/Holo_Transferrin_Human_11_121/

HOLO-TRANSFERRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HOLO-TRANSFERRIN Suppliers

Merck Life Science Private Limited
Tel
--
Fax
--
Country
India
ProdList
101
Advantage
58
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View Lastest Price from HOLO-TRANSFERRIN manufacturers

Watson Biotechnology Co.,Ltd
Product
Transferrin 11096-37-0
Price
US $0.00-0.00/G
Min. Order
1G
Purity
99%
Supply Ability
100G
Release date
2024-08-10
Hebei Weibang Biotechnology Co., Ltd
Product
HOLO-TRANSFERRIN 11096-37-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
HOLO-TRANSFERRIN 11096-37-0
Price
US $30.00-3.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-26

11096-37-0, HOLO-TRANSFERRINRelated Search:


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