ChemicalBook > CAS DataBase List > Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Uses

Product Name: Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.: 167465-99-8
Chemical Name: Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)
Synonyms: tert-Butyl ((1S,3R);Bictegravir Impurity 26;(1R,3S)-3-aminocyclopentan-1-ol;(1R,3S)-3-(Boc-amino)cyclopentanol;Benzoicacid,6-ethynyl-,methylester;cis-tert-butyl-3-hydroxycyclopentylcarbamate;(1S,3R)-tert-butyl(3-hydroxycyclopentyl)catbaMte;(1S,3R)-3-Hydroxycyclopentyl] tert-butyl carbamate;tert-butyl N-[(1S,3R)-3-hydroxycyclopentyl]carbamate;[(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester
CBNumber: CB21060890
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 167465-99-8.mol

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Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) Property

Boiling point:: 321℃
Density: 1.08
Flash point:: 148℃
storage temp.: 2-8°C
pka: 12.27±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-7-4-5-8(12)6-7/h7-8,12H,4-6H2,1-3H3,(H,11,13)/t7-,8+/m0/s1
InChIKey: SBUKINULYZANSP-JGVFFNPUSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@H]1CC[C@@H](O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B814475
Product name: tert-Butyl((1S,3R)-3-Hydroxycyclopentyl)carbamate
Packaging: 50mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-W019801
Product name: Carbamicacid,N-[(1S,3R)-3-hydroxycyclopentyl]-,1,1-dimethylethylester
Purity: 99.75%
Packaging: 100mg
Price: $67
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141944
Product name: tert-Butyl ((1S,3R)-3-hydroxycyclopentyl)carbamate
Packaging: 50mg
Price: $71
Updated: 2021/12/16

ChemScene

Product number: CS-W019801
Product name: Carbamicacid,N-[(1S,3R)-3-hydroxycyclopentyl]-,1,1-dimethylethylester
Purity: 99.75%
Packaging: 250mg
Price: $111
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141944
Product name: tert-Butyl ((1S,3R)-3-hydroxycyclopentyl)carbamate
Packaging: 100mg
Price: $124
Updated: 2021/12/16

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Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production

Uses

In asymmetric synthesis, the synthesis of chiral catalysts or chiral auxiliaries is crucial. Chiral amino alcohols are widely used as ligands or catalysts for catalyzing asymmetric synthetic reactions and are also important precursors for the synthesis of many chiral drugs, natural products, and chemical and biological functional materials.

Synthesis

99027-90-4

167465-99-8

Tert-butyl 2-oxa-3-azabicyclo[2.2.1]hept-5-ene-3-carboxylate (8.0 g, 40.56 mmol, 1.00 eq.) was mixed with palladium/carbon catalyst (0.5 g) in methanol (100 mL). The reaction was stirred at 60 °C for 48 hours under hydrogen atmosphere. Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration. The catalyst was washed with methanol (3 x 10 mL). The filtrate and washings were combined and concentrated in vacuum to give tert-butyl N-[(1S,3R)-3-hydroxycyclopentyl]carbamate (6.5 g, 80% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, D2O, ppm): δ 4.72 (1H, s), 4.55 (1H, s), 1.92-1.87 (3H, m), 1.76-1.60 (3H, m), 1.50 (9H, s).

References

[1] Patent: WO2013/155338, 2013, A2. Location in patent: Page/Page column 144
[2] Patent: US2015/329503, 2015, A1. Location in patent: Paragraph 0646

Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) manufacturers

Career Henan Chemical Co

Product: Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) 167465-99-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

Career Henan Chemical Co

Product: Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) 167465-99-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

167465-99-8, Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)Related Search:

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Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester

(1R,3S)-3-(Boc-amino)cyclopentanol

Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI)

[(1S,3R)-3-Hydroxycyclopentyl]carbamic acid tert-butyl ester

(1R,3S)-3-aminocyclopentan-1-ol

(1S,3R)-tert-butyl(3-hydroxycyclopentyl)catbaMte

cis-tert-butyl-3-hydroxycyclopentylcarbamate

tert-butyl N-[(1S,3R)-3-hydroxycyclopentyl]carbamate

[(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester

Carbamic acid, N-[(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester

tert-Butyl ((1S,3R)-3-hydroxycyclopentyl)carbamate - H10877

tert-Butyl ((1S,3R)

Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethyl...

Benzoicacid,6-ethynyl-,methylester

(1S,3R)-3-Hydroxycyclopentyl] tert-butyl carbamate

Bictegravir Impurity 26

167465-99-8

465-99-8

10772-05-8

N-BOC