ChemicalBook > CAS DataBase List > Mupadolimab
Mupadolimab
- Product Name
- Mupadolimab
- CAS No.
- 2451856-97-4
- Chemical Name
- Mupadolimab
- Synonyms
- CPI-006;Mupadolimab;Mupadolimab (anti-CD73);Research Grade Mupadolimab;Research Grade Mupadolimab(DHD46604)
- CBNumber
- CB210617076
- Formula Weight
- 0
- MOL File
- Mol file
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Mupadolimab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
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Mupadolimab Chemical Properties,Usage,Production
Uses
Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73POS B cells[1].
in vivo
Mupadolimab (10 mg/kg; i.p.; daily for 15 days) stimulates antigen specific humoral immunity in SARS-CoV-2 infected NSG-SGM3 mice[1].
| Animal Model: | NSG-SGM3 mice, immunized with an emulsion of 50 μg full length spike protein from SARS-CoV-2 and Freund’s Incomplete Adjuvant subcutaneously on both the left and right flank (25 μg/side)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection, daily for 15 days |
| Result: | Mice treated with the drug made antibodies to the immunizing TS protein; but not to the control nucleocapsid SARS-CoV-2 viral protein. |
References
[1] Miller R A, et al. Clinical results with a B cell activating anti-CD73 antibody for the immunotherapy of Covid-19. medRxiv, 2021.
Mupadolimab Preparation Products And Raw materials
Raw materials
Preparation Products
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Mupadolimab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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