Ormutivimab

Product Name: Ormutivimab
CAS No.: 2449086-91-1
Chemical Name: Ormutivimab
Synonyms: Ormutivimab;Research Grade Ormutivimab;Research Grade Ormutivimab (DVV03905)
CBNumber: CB210617117
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Ormutivimab Chemical Properties,Usage,Production

Uses

Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model[1][2].

in vivo

Ormutivimab (20 IU/kg; i.m.; single dose) protects beagles from a lethal challenge of street RABV BD06^[1].
Ormutivimab (20 IU/kg, 100 IU/kg; i.m.; single dose) protects challenged Kunming mice against various rabies virus^[1].

Animal Model:	Balb/c mice challenge model with rabies virus^[1]
Dosage:	20 IU/kg, 100 IU/kg
Administration:	Intramuscular injection; single dose after 4 hr after infection
Result:	Protected mice from rabies CVS-24 and GZ-1 isolates at a comparable rate (90%) to that of HRIG, human antirabies immune globulin.

References

[1] Zhai LL, et al. Efficacy of ormutivimab, a novel recombinant human anti-rabies monoclonal antibody, in post-exposure prophylaxis animal models. Travel Med Infect Dis. 2022 Mar-Apr;46:102267. DOI:10.1016/j.tmaid.2022.102267
[2] Zhang J, et al. Population Pharmacodynamic Analyses of Human Anti-Rabies Virus Monoclonal Antibody (Ormutivimab) in Healthy Adult Subjects. Vaccines (Basel). 2022 Jul 29;10(8):1218. DOI:10.3390/vaccines10081218

Ormutivimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Ormutivimab Suppliers

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2449086-91-1, OrmutivimabRelated Search:

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Ormutivimab

Research Grade Ormutivimab (DVV03905)

Research Grade Ormutivimab

2449086-91-1