L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-

Product Name: L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-
CAS No.: 2417491-82-6
Chemical Name: L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-
Synonyms: AXT-107;Gersizangitide;Gersizangitide (AXT-107);L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-
CBNumber: CB210690930
Molecular Formula: C111H167N29O28
Formula Weight: 2355.73
MOL File: 2417491-82-6.mol

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L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl- Property

Density: 1.42±0.1 g/cm3(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl- Chemical Properties,Usage,Production

Uses

Gersizangitide (AXT107) is an angiogenic inhibitor peptide containing 20 amino acids.Gersizangitide is a VEGF-A and VEGF-C inhibitor and a Tie2 activator. Gersizangitide is a collagen IV-derived peptide that blocks VEGF receptor signaling and suppresses vascular leakage in ischemic retinopathy and choroidal neovascularization[1].

IC 50

Tie2; VEGF-A; VEGF-C

References

[1] Fei X, et al. Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration. Arch Pharm Res. 2024 Jun;47(6):538-557. DOI:10.1007/s12272-024-01503-3

L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl- Suppliers

China 22 United States 1 Global 23

Chengdu Youngshe Chemical Co., Ltd.

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Hangzhou Peptidego Biotech Co.,Ltd.

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Zhejiang J&C Biological Technology Co.,Limited

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Shaoxing Junyu Biotechnology Co., LTD

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TargetMol Chemicals Inc.

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Hangzhou Sinoda Pharmaceutical Technology Co. LTD

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2417491-82-6, L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-Related Search:

H-TYR-GLY-PHE-GLY-GLY-OH Tat-Beclin 1 Peptide Tau Peptide (275-305) (Repeat 2 Domain) L-Lysine, L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-alanyl-L-glutaminyl-L-arginyl-L-tyrosylglycyl-L-arginyl-L-α-glutamyl-L-leucyl-L-arginyl-L-arginyl-L-methionyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-lysyl- L-Leucine, L-histidyl-L-tyrosyl-L-leucyl-L-seryl-L-threonyl-L-glutaminyl-L-seryl-L-alanyl- Parstatin (human)

L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-

Gersizangitide

AXT-107

Gersizangitide (AXT-107)

2417491-82-6

C111H167N29O28