Herbacetin
- Product Name
- Herbacetin
- CAS No.
- 527-95-7
- Chemical Name
- Herbacetin
- Synonyms
- Herbacetin-RM;Isoarticulatidin;HERBACETIN(P)(PLEASE CALL);Herbacetin,inhibit,Inhibitor;4',5,7,8-Tetrahydroxyflavonol;3,4',5,7,8-pentahydroxyflavone;Herbacetin 8-Hydroxykaempferol;Herbacetin, 98%, from Rhodiola rosea L.;3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
- CBNumber
- CB21074417
- Molecular Formula
- C15H10O7
- Formula Weight
- 302.24
- MOL File
- 527-95-7.mol
Herbacetin Property
- Melting point:
- 284℃
- Boiling point:
- 618.7±55.0 °C(Predicted)
- Density
- 1.799
- solubility
- DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM) - form
- A crystalline solid
- pka
- 6.49±0.40(Predicted)
- color
- Light yellow to yellow
- LogP
- 1.140 (est)
N-Bromosuccinimide Price
- Product number
- 19285
- Product name
- Herbacetin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19285
- Product name
- Herbacetin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 19285
- Product name
- Herbacetin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 19285
- Product name
- Herbacetin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $397
- Updated
- 2024/03/01
- Product number
- H235130
- Product name
- Herbacetin
- Packaging
- 1mg
- Price
- $55
- Updated
- 2021/12/16
Herbacetin Chemical Properties,Usage,Production
Chemical Properties
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.
Uses
Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.
Definition
ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.
Biological Activity
Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.
in vivo
Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM in+ mice with no overt toxicity.
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Herbacetin Preparation Products And Raw materials
Raw materials
Preparation Products
Herbacetin Suppliers
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View Lastest Price from Herbacetin manufacturers
- Product
- Herbacetin 527-95-7
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 100 g
- Release date
- 2020-08-12
- Product
- Herbacetin 527-95-7
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24