Herbacetin

ChemicalBook > CAS DataBase List > Herbacetin

Product Name: Herbacetin
CAS No.: 527-95-7
Chemical Name: Herbacetin
Synonyms: Herbacetin-RM;Isoarticulatidin;HERBACETIN(P)(PLEASE CALL);Herbacetin,inhibit,Inhibitor;4',5,7,8-Tetrahydroxyflavonol;3,4',5,7,8-pentahydroxyflavone;Herbacetin 8-Hydroxykaempferol;Herbacetin, 98%, from Rhodiola rosea L.;3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
CBNumber: CB21074417
Molecular Formula: C15H10O7
Formula Weight: 302.24
MOL File: 527-95-7.mol

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Herbacetin Property

Melting point:: 284℃
Boiling point:: 618.7±55.0 °C(Predicted)
Density: 1.799
solubility: DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM)
form: A crystalline solid
pka: 6.49±0.40(Predicted)
color: Light yellow to yellow
LogP: 1.140 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19285
Product name: Herbacetin
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19285
Product name: Herbacetin
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19285
Product name: Herbacetin
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 19285
Product name: Herbacetin
Purity: ≥98%
Packaging: 25mg
Price: $397
Updated: 2024/03/01

TRC

Product number: H235130
Product name: Herbacetin
Packaging: 1mg
Price: $55
Updated: 2021/12/16

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Herbacetin Chemical Properties,Usage,Production

Chemical Properties

Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.

Uses

Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.

Definition

ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.

Biological Activity

Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.

in vivo

Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM ⁱⁿ⁺ mice with no overt toxicity.

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Herbacetin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Herbacetin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Herbacetin 527-95-7
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-12

Career Henan Chemical Co

Product: Herbacetin 527-95-7
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

527-95-7, HerbacetinRelated Search:

Quercetin-7-O-β-D-glucopyranoside Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers) ROSARIN Herbacetin 7-rhamnoside Leucoside 7,8-Dihydroxycoumarin Kaempferol Phloretin 3,7,3',4'-TETRAMETHYLGOSSYPETIN GOSSYPIN 5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone GOSSYPETIN HERBACETIN-3,8-DIGLUCOPYRANOSIDE Herbacetin 3,3',4',5,6,7,8-heptamethoxyflavone HERBACETIN 8-GLUCOSIDE-3-SOPHORISIDE HEPTAMETHOXYFLAVONE HERBACETIN-7-O-GLUCORHAMNOSIDE

3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one

3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one

3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Herbacetin, 98%, from Rhodiola rosea L.

3,5,7,8,4'-Pentahydroxyflavone/3,5,7,3',4',8-Hexahydroxyflavone - Herbacetin/Gossypetin mixture

HERBACETIN(P)(PLEASE CALL)

3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Isoarticulatidin

4',5,7,8-Tetrahydroxyflavonol

4H-1-Benzopyran-4-one,3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-

Herbacetin 8-Hydroxykaempferol

Herbacetin,inhibit,Inhibitor

3,4',5,7,8-pentahydroxyflavone

Herbacetin-RM

527-95-7

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Penta-substituted Flavones