Fantofarone

Product Name: Fantofarone
CAS No.: 114432-13-2
Chemical Name: Fantofarone
Synonyms: CS-2766;SR-33557;Fantofarone;Fantofarone, 10 mM in DMSO;FANTOFARONE;SR-33557;SR33557; 114432-13-2;Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels;2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine;2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[2-(propan-2-yl)indolizin-1-yl]sulfonyl}phenoxy)propyl]amine;3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine;Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-
CBNumber: CB21118032
Molecular Formula: C31H38N2O5S
Formula Weight: 550.71
MOL File: 114432-13-2.mol

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Fantofarone Property

Melting point:: 82-83°
Density: dz 1.21 g/cm3
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 8.34 ± 0.05(at 25℃)
color: Light yellow to yellow
InChIKey: ITAMRBIZWGDOHW-UHFFFAOYSA-N
SMILES: C1(CCN(C)CCCOC2=CC=C(S(C3=C4N(C=CC=C4)C=C3C(C)C)(=O)=O)C=C2)=CC=C(OC)C(OC)=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26381
Product name: Fantofarone
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 26381
Product name: Fantofarone
Packaging: 25mg
Price: $745
Updated: 2024/03/01

Cayman Chemical

Product number: 26381
Product name: Fantofarone
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 26381
Product name: Fantofarone
Packaging: 10mg
Price: $321
Updated: 2024/03/01

ChemScene

Product number: CS-0025047
Product name: Fantofarone
Purity: 98.56%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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Fantofarone Chemical Properties,Usage,Production

Uses

Fantofarone is a highly potent Calcium Channel antagonist.

Biological Activity

Fantofarone is a potent antagonist of Calcium Channels.

in vitro

It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites.

in vivo

Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective.

References

[1] Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40. DOI:10.1016/s0006-2952(97)00482-6
[2] Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50. DOI:10.1016/s0006-2952(98)00026-4

Fantofarone Preparation Products And Raw materials

Raw materials

Preparation Products

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Fantofarone Suppliers

China 40 South Korea 1 United Kingdom 1 United States 9 Global 51

Shanghai Dongyang Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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114432-13-2, FantofaroneRelated Search:

INDOLIZINE Fantofarone

Fantofarone

2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine

SR-33557

3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine

FANTOFARONE;SR-33557;SR33557; 114432-13-2

CS-2766

Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-

Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels

2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[2-(propan-2-yl)indolizin-1-yl]sulfonyl}phenoxy)propyl]amine

Fantofarone, 10 mM in DMSO

114432-13-2

C31H38N2O5S

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