(R)-1-N-BOC-PIPECOLAMIDE
- Product Name
- (R)-1-N-BOC-PIPECOLAMIDE
- CAS No.
- 848488-91-5
- Chemical Name
- (R)-1-N-BOC-PIPECOLAMIDE
- Synonyms
- Boc-D-2-Piperidinecarboxamide;(R)-1-Boc-2-carbamoylpiperidine;N-Boc-D-2-piperidinecarboxamide;(R)-1-Boc-2-piperidinecarboxaMide;(R)-1-Boc-2-(aminocarbonyl)piperidine;tert-Butyl (R)-2-carbamoylpiperidine-1-carboxylate;(R)-tert-butyl 2-carbamoylpiperidine-1-carboxylate;(R)-tert-Butyl 2-carbamoyllpiperidine-1-carboxylate;(R)-2-Carbamoyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-
- CBNumber
- CB21118582
- Molecular Formula
- C11H20N2O3
- Formula Weight
- 228.29
- MOL File
- 848488-91-5.mol
(R)-1-N-BOC-PIPECOLAMIDE Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B662115
- Product name
- (R)-1-N-Boc-Pipecolamide
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB148065
- Product name
- (R)-1-N-Boc-pipecolamide
- Packaging
- 100mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- CCH0003265
- Product name
- (R)-2-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 0.25G
- Price
- $240
- Updated
- 2021/12/16
- Product number
- FB148065
- Product name
- (R)-1-N-Boc-pipecolamide
- Packaging
- 250mg
- Price
- $227.5
- Updated
- 2021/12/16
- Product number
- FB148065
- Product name
- (R)-1-N-Boc-pipecolamide
- Packaging
- 500mg
- Price
- $395
- Updated
- 2021/12/16
(R)-1-N-BOC-PIPECOLAMIDE Chemical Properties,Usage,Production
Synthesis
28697-17-8
848488-91-5
Step B. Synthesis of tert-butyl (2R)-2-(aminocarbonyl)piperidine-1-carboxylate: To a mixture of (2R)-1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (2.29 g, 10 mmol), ammonium chloride (3.21 g, 60 mmol), and DMF (70 mL) was added HATU (5.60 g, 14.7 mmol) at 0 °C and DIPEA (3.88 g, 30 mmol). The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with H2O (100 mL) and extracted with EtOAc (3 x 100 mL). The organic phases were combined and washed sequentially with 10% Na2CO3 solution (2 × 30 mL), brine (2 × 30 mL) and then dried with Na2SO4. After filtration and concentration, it was purified by MPLC on silica gel using hexane/EtOAc (1:1) as eluent to afford R-N-Boc-prolinamide as a white solid.1H NMR (400 MHz, CDCl3) δ: 1.46 (s, 9H), 1.63 (m, 2H), 2.22 (m, 1H), 2.91 (m, 1H), 3.06 (m, 3H), 4.01 (m, 1H), 4.71 (m, 1H), 6.46 (br, 2H).MS (ESI) m/z: 228.92 (M+H)+.
References
[1] Patent: WO2005/115986, 2005, A1. Location in patent: Page/Page column 103
[2] Patent: WO2006/116764, 2006, A1. Location in patent: Page/Page column 121; 151
[3] Patent: US2008/300279, 2008, A1. Location in patent: Page/Page column 9
[4] ACS Infectious Diseases, 2018, vol. 4, # 7, p. 1130 - 1145
(R)-1-N-BOC-PIPECOLAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-1-N-BOC-PIPECOLAMIDE Suppliers
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