(+/-)-THREO-3-METHYLGLUTAMIC ACID

(+/-)-THREO-3-METHYLGLUTAMIC ACID Property

Boiling point:

329.4±32.0 °C(Predicted)

Density 

1.329±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

H2O: >1.5mg/dL

form 

powder

pka

2.20±0.10(Predicted)

color 

white to off-white

Water Solubility 

H2O: >1.5mg/dL

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(+/-)-THREO-3-METHYLGLUTAMIC ACID Chemical Properties,Usage,Production

Uses

A highly selective and potent agonist for kainate receptors.

Biological Activity

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EA at function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

IC 50

EAAT2; EAAT4