(+/-)-THREO-3-METHYLGLUTAMIC ACID

Product Name: (+/-)-THREO-3-METHYLGLUTAMIC ACID
CAS No.: 63088-04-0
Chemical Name: (+/-)-THREO-3-METHYLGLUTAMIC ACID
Synonyms: 3MG;T3MG;Threo-3-Me-Glu-OH;(3S)-rel-3-Methyl-;threo-3-Methylglutamate;threo-β-methylglutamic acid;threo-3-Methyl-DL-glutamic Acid;(±)-threo-3-Methylglutamic acid;(3S)-rel-3-Methyl-D-glutamic Acid;(+/-)-THREO-3-METHYLGLUTAMIC ACID
CBNumber: CB2112161
Molecular Formula: C6H11NO4
Formula Weight: 161.16
MOL File: 63088-04-0.mol

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(+/-)-THREO-3-METHYLGLUTAMIC ACID Property

Boiling point:: 329.4±32.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: H2O: >1.5mg/dL
form: powder
pka: 2.20±0.10(Predicted)
color: white to off-white
Water Solubility: H2O: >1.5mg/dL

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T2455
Product name: T3MG
Purity: (single spot, TLC)
Packaging: 5mg
Price: $173
Updated: 2025/07/31

Sigma-Aldrich

Product number: T2455
Product name: T3MG
Purity: (single spot, TLC)
Packaging: 25mg
Price: $558
Updated: 2025/07/31

TRC

Product number: M311585
Product name: (+/-)-threo-3-MethylglutamicAcid
Packaging: 10mg
Price: $145
Updated: 2021/12/16

ApexBio Technology

Product number: B6461
Product name: (±)-threo-3-Methylglutamicacid
Packaging: 10mg
Price: $188
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0006679
Product name: (+/-)-THREO-3-METHYLGLUTAMIC ACID
Purity: 95.00%
Packaging: 10MG
Price: $315
Updated: 2021/12/16

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(+/-)-THREO-3-METHYLGLUTAMIC ACID Chemical Properties,Usage,Production

Uses

A highly selective and potent agonist for kainate receptors.

Biological Activity

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EA at function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

IC 50

EAAT2; EAAT4

(+/-)-THREO-3-METHYLGLUTAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-THREO-3-METHYLGLUTAMIC ACID Suppliers

Canada 1 China 19 Germany 1 India 1 Japan 2 United Kingdom 2 United States 4 USA 1 Global 31

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63088-04-0, (+/-)-THREO-3-METHYLGLUTAMIC ACIDRelated Search:

DL-Glutamic acid (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE KAINIC ACID LY 341495 (2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID KAINIC ACID DIMETHYL ESTER HYDROCHLORIDE (2S,3R,4S)-CCG (2R,3S)-BETA-P-CHLOROPHENYLGLUTAMIC ACID DCG IV (+/-)-THREO-3-METHYLGLUTAMIC ACID (+/-)-TRANS-1-AMINO-1-CARBOXYCYCLOPENTANE-2-ACETIC ACID FMOC-(2S, 3S)-GLU(3-ME) (2S,2'R,3'R)-2-(1'-3H,2',3'-DICARBOXYCYCLOPROPYL)GLYCINE ABHXD-I HYDROCHLORIDE XE-CCG-I PCCG-4 BOC-(2S, 3S)-GLU(3-ME) KAINIC ACID, [VINYLIDENE-3H]

(+/-)-THREO-3-METHYLGLUTAMIC ACID

Threo-3-Me-Glu-OH

(3S)-rel-3-Methyl-D-glutamic Acid

threo-3-Methyl-DL-glutamic Acid

D-GlutaMic acid, 3-Methyl-, (3S)-rel-

(3S)-rel-3-Methyl-

T3MG

3MG

threo-3-Methylglutamate

threo-β-methylglutamic acid

(+/-)-THREO-3-METHYLGLUTAMIC ACID USP/EP/BP

(±)-threo-3-Methylglutamic acid

(+/-)-THREO-3-METHYLGLUTAMIC ACID

63088-04-0

Amino Acids & Derivatives

Chiral Reagents

Neurochemicals