ChemicalBook > CAS DataBase List > N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt

Uses

Product Name: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
CAS No.: 208167-83-3
Chemical Name: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
Synonyms: tert-Butyl 4-(2-chloroethyl);1-Boc-4-(2-chloroethyl)piperazine;N-Boc-N'-(2-Chloroethyl)piperazine;1-Boc-4-(2-chloroethyl)piperazine,97%;1-Boc-4-(2-chloroethyl)piperazine, 97%;N-BOC-N''-(2-CHLOROETHYL)PIPERAZINE HYDROCHLORIDE;tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate;N-BOC-Nzzhlxy-(2-Chloroethyl)piperazine hydrochloride;N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt;tert-Butyl 4-(2-chloroethyl)tetrahydropyrazine-1-carboxylate
CBNumber: CB21122356
Molecular Formula: C11H21ClN2O2
Formula Weight: 248.75
MOL File: 208167-83-3.mol

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N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Property

Melting point:: 67-69°C
Boiling point:: 318.4±37.0 °C(Predicted)
Density: 1.106±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Slightly Soluble (7.2 g/L) (25°C).
form: Crystalline Powder
pka: 6.13±0.10(Predicted)
color: White to light brown
InChI: InChI=1S/C11H21ClN2O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9H2,1-3H3
InChIKey: MYOWELLYEZMECA-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(CCCl)CC1
CAS DataBase Reference: 208167-83-3

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B807083
Product name: tert-Butyl4-(2-Chloroethyl)piperazine-1-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 046534
Product name: TERT-BUTYL 4-(2-CHLOROETHYL)PIPERAZINE-1-CARBOXYLATE
Purity: >95%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: OR15245
Product name: 4-(2-Chloroethyl)piperazine,N1-BOCprotected
Packaging: 1g
Price: $48
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-5-Q4
Product name: 4-(2-Chloroethyl)piperazine, N1-Boc protected
Packaging: 1g
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 046534
Product name: TERT-BUTYL 4-(2-CHLOROETHYL)PIPERAZINE-1-CARBOXYLATE
Purity: >95%
Packaging: 5g
Price: $305
Updated: 2021/12/16

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N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(2-Chloroethyl)piperazine-1-carboxylate is used in a study of anticancer activity of dihydroxyanthrathiazolediones.

Uses

By the direct condensation of chloroalkyl piperazine, nitrogen mustard benzaldehyde, and pyrrole anticancer activity to bel-7404 liver cancer cells was found.

Synthesis

107-04-0

57260-71-6

208167-83-3

General procedure for the synthesis of 1-BOC-4-(2-chloroethyl)piperazine from 1-bromo-2-chloroethane and N-BOC-piperazine: firstly, di-tert-butyl dicarbonate (18.98g, 87.07mmol) was added slowly and dropwise to the suspension of dipiperazine (30.00g, 348.27mmol) and sodium carbonate (106g, 348.27mmol) in dichloromethane (200ml) 87.07 mmol) in dichloromethane solution (30 ml), the titration process lasted for 1 hour and the reaction was carried out at room temperature. After completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. At the end of the reaction, the mixture was mixed with water (100 ml) and the organic phase was separated. The organic layer was dried with magnesium sulfate followed by evaporation under reduced pressure to remove the solvent. The residue was dissolved in dichloromethane (150 ml) and sodium carbonate (15.55 g, 146.77 mmol) and 1-bromo-2-chloroethane (21.05 g, 146.77 mmol) were added. The mixture was stirred at room temperature for one weekend. After completion of the reaction, the mixture was again mixed with water (100 ml) and the organic phase was separated. The organic layer was dried with magnesium sulfate and evaporated under reduced pressure to remove the solvent. Finally, the residue was purified by silica gel column chromatography using hexane and ethyl acetate as eluents to give 6.85 g of 1-Boc-4-(2-chloroethyl)piperazine.

References

[1] Patent: WO2014/145686, 2014, A2. Location in patent: Paragraph 0382-0383
[2] RSC Advances, 2015, vol. 5, # 125, p. 103172 - 103183

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt manufacturers

Career Henan Chemical Co

Product: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt 208167-83-3
Price: US $1.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

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208167-83-3