N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt

Uses

Product Name: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
CAS No.: 208167-83-3
Chemical Name: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
Synonyms: tert-Butyl 4-(2-chloroethyl);1-Boc-4-(2-chloroethyl)piperazine;N-Boc-N'-(2-Chloroethyl)piperazine;1-Boc-4-(2-chloroethyl)piperazine,97%;1-Boc-4-(2-chloroethyl)piperazine, 97%;N-BOC-N''-(2-CHLOROETHYL)PIPERAZINE HYDROCHLORIDE;tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate;N-BOC-Nzzhlxy-(2-Chloroethyl)piperazine hydrochloride;N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt;tert-Butyl 4-(2-chloroethyl)tetrahydropyrazine-1-carboxylate
CBNumber: CB21122356
Molecular Formula: C11H21ClN2O2
Formula Weight: 248.75
MOL File: 208167-83-3.mol

More

Less

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Property

Melting point:: 67-69°C
Boiling point:: 318.4±37.0 °C(Predicted)
Density: 1.106±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Slightly Soluble (7.2 g/L) (25°C).
form: Crystalline Powder
pka: 6.13±0.10(Predicted)
color: White to light brown
InChI: InChI=1S/C11H21ClN2O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9H2,1-3H3
InChIKey: MYOWELLYEZMECA-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(CCCl)CC1
CAS DataBase Reference: 208167-83-3

More

Less

Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B807083
Product name: tert-Butyl4-(2-Chloroethyl)piperazine-1-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 046534
Product name: TERT-BUTYL 4-(2-CHLOROETHYL)PIPERAZINE-1-CARBOXYLATE
Purity: >95%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: OR15245
Product name: 4-(2-Chloroethyl)piperazine,N1-BOCprotected
Packaging: 1g
Price: $48
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-5-Q4
Product name: 4-(2-Chloroethyl)piperazine, N1-Boc protected
Packaging: 1g
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 046534
Product name: TERT-BUTYL 4-(2-CHLOROETHYL)PIPERAZINE-1-CARBOXYLATE
Purity: >95%
Packaging: 5g
Price: $305
Updated: 2021/12/16

More

Less

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(2-Chloroethyl)piperazine-1-carboxylate is used in a study of anticancer activity of dihydroxyanthrathiazolediones.

Uses

By the direct condensation of chloroalkyl piperazine, nitrogen mustard benzaldehyde, and pyrrole anticancer activity to bel-7404 liver cancer cells was found.

Synthesis

107-04-0

57260-71-6

208167-83-3

General procedure for the synthesis of 1-BOC-4-(2-chloroethyl)piperazine from 1-bromo-2-chloroethane and N-BOC-piperazine: firstly, di-tert-butyl dicarbonate (18.98g, 87.07mmol) was added slowly and dropwise to the suspension of dipiperazine (30.00g, 348.27mmol) and sodium carbonate (106g, 348.27mmol) in dichloromethane (200ml) 87.07 mmol) in dichloromethane solution (30 ml), the titration process lasted for 1 hour and the reaction was carried out at room temperature. After completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. At the end of the reaction, the mixture was mixed with water (100 ml) and the organic phase was separated. The organic layer was dried with magnesium sulfate followed by evaporation under reduced pressure to remove the solvent. The residue was dissolved in dichloromethane (150 ml) and sodium carbonate (15.55 g, 146.77 mmol) and 1-bromo-2-chloroethane (21.05 g, 146.77 mmol) were added. The mixture was stirred at room temperature for one weekend. After completion of the reaction, the mixture was again mixed with water (100 ml) and the organic phase was separated. The organic layer was dried with magnesium sulfate and evaporated under reduced pressure to remove the solvent. Finally, the residue was purified by silica gel column chromatography using hexane and ethyl acetate as eluents to give 6.85 g of 1-Boc-4-(2-chloroethyl)piperazine.

References

[1] Patent: WO2014/145686, 2014, A2. Location in patent: Paragraph 0382-0383
[2] RSC Advances, 2015, vol. 5, # 125, p. 103172 - 103183

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Suppliers

China 66 India 2 Ireland 1 United Kingdom 4 United States 7 Global 80

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 1356
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 2000
Advantage: 58

More

Less

View Lastest Price from N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt manufacturers

Career Henan Chemical Co

Product: N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt 208167-83-3
Price: US $1.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

208167-83-3, N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride saltRelated Search:

tert-butyl 4-(2-chloropyrimidin-4-yl)piperidine-1-carboxylate 1-Boc-4-(2-chloro-4-nitrophenyl)piperazine HEPES 4-CHLOROACETYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt

N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt

N-BOC-N''-(2-CHLOROETHYL)PIPERAZINE HYDROCHLORIDE

tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate

N-BOC-Nzzhlxy-(2-Chloroethyl)piperazine hydrochloride

1-Boc-4-(2-chloroethyl)piperazine, 97%

tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(2-chloroethyl)piperazine

2-(benzyloxy)-5-fluorobenzaldehydetert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate

4-(2-Chloroethyl)piperazine-1-carboxylic acid tert-butyl ester

N-Boc-N'-(2-Chloroethyl)piperazine

tert-Butyl 4-(2-chloroethyl)

1-Piperazinecarboxylic acid, 4-(2-chloroethyl)-, 1,1-dimethylethyl ester

1-Boc-4-(2-chloroethyl)piperazine,97%

tert-Butyl 4-(2-chloroethyl)tetrahydropyrazine-1-carboxylate

1-Boc-4-(2-chloroethyl)piperazine

208167-83-3