SUBERIC ACID MONOMETHYL ESTER
- Product Name
- SUBERIC ACID MONOMETHYL ESTER
- CAS No.
- 3946-32-5
- Chemical Name
- SUBERIC ACID MONOMETHYL ESTER
- Synonyms
- 8-Methoxy-8-oxooctanoic acid;MONOMETHYL SUBERATE;Monomethyl octanoate;MonomethylSuberate>Monomethyl Octaneoate;Suberic acid MonoMethy;Monomethyl octanedioate;SUBERIC ACID MONOMETHYL;METHYL HYDROGEN SUBERATE;Testosterone Impurity 47
- CBNumber
- CB2114024
- Molecular Formula
- C9H16O4
- Formula Weight
- 188.22
- MOL File
- 3946-32-5.mol
SUBERIC ACID MONOMETHYL ESTER Property
- Melting point:
- 17-19 °C (lit.)
- Boiling point:
- 185-186 °C/18 mmHg (lit.)
- Density
- 1.047 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.444(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- Colourless
- InChI
- InChI=1S/C9H16O4/c1-13-9(12)7-5-3-2-4-6-8(10)11/h2-7H2,1H3,(H,10,11)
- InChIKey
- KOVPXZDUVJGGFU-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)CCCCCCC(O)=O
- CAS DataBase Reference
- 3946-32-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 242446
- Product name
- Suberic acid monomethyl ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $53.7
- Updated
- 2025/07/31
- Product number
- 242446
- Product name
- Suberic acid monomethyl ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S0440
- Product name
- Monomethyl Suberate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- S0440
- Product name
- Monomethyl Suberate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- M542590
- Product name
- Monomethyl Suberate
- Packaging
- 250g
- Price
- $1390
- Updated
- 2021/12/16
SUBERIC ACID MONOMETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
colorless low melting solid
Uses
Monomethyl Suberate was used in the synthetic preparation of Prostaglandin E1 (P838600), a primary prostaglandin and a peripheral vasodilator.
Uses
Suberic acid monomethyl ester was used in the synthetic preparation of Prostaglandin E1 (P838600), a primary prostaglandin and a peripheral vasodilator.
General Description
The effects of suberic acid monomethyl ester (monomethyl suberate) on liver lactate metabolism was studied.
Synthesis
1732-09-8
3946-32-5
General method: 5.1.2 Synthesis of 7-methoxy-7-oxoheptanoic acid (84): a methanolic (150 ml) solution of KOH (5.87 g, 104.65 mmol) was slowly added dropwise to dimethyl heptanedioate (82, 16.94 g, 90 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the solvent was removed under reduced pressure and subsequently extracted by adding ether (100 ml) and water (200 ml). The organic phase was separated and concentrated to give yellow oil 82 (5.08 g, 30% yield). The aqueous phase was acidified to pH 3 with concentrated hydrochloric acid and extracted with ether (100 ml x 3). The combined organic layers were washed with brine (100 ml x 3), dried over magnesium sulfate and the solvent was concentrated under reduced pressure. The product was purified by silica gel column chromatography to give colorless oil 84 (5.96 g, 38% yield). Compound 85 was synthesized using the same method.5.1.2.1 Synthesis of 8-methoxy-8-oxooctanoic acid (85): 44% yield.ESI-MS m/z: 187.4 [M-H]-; 1H NMR (DMSO-d6) δ 1.21-1.32 (m, 4H), 1.43-1.53 (m, 4H), 2.18 (t, J=7.2 Hz, 2H), 2.29 (t, J=7.2Hz, 2H), 3.58 (s, 3H), 11.97 (s, 1H).
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 15, p. 1713 - 1714
[2] Synthetic Communications, 1995, vol. 25, # 5, p. 739 - 742
[3] European Journal of Organic Chemistry, 1999, # 10, p. 2655 - 2662
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 16, p. 4253 - 4256
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5766 - 5775
SUBERIC ACID MONOMETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SUBERIC ACID MONOMETHYL ESTER manufacturers
- Product
- SUBERIC ACID MONOMETHYL ESTER 3946-32-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-02
- Product
- SUBERIC ACID MONOMETHYL ESTER 3946-32-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- SUBERIC ACID MONOMETHYL ESTER 3946-32-5
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04