ChemicalBook > CAS DataBase List > D-(-)-MANDELIC ACID BENZYL ESTER

D-(-)-MANDELIC ACID BENZYL ESTER

Product Name
D-(-)-MANDELIC ACID BENZYL ESTER
CAS No.
97415-09-3
Chemical Name
D-(-)-MANDELIC ACID BENZYL ESTER
Synonyms
DOMIT-002;(R)-BENZYL MANDELATE;BENZYL D-(-)-MANDELATE;BENZYL (R)-(-)-MANDELATE;BenzylD-(-)-Mandelate>Benzyl (R)-(-)-mandelate 99%;D-(-)-MANDELIC ACID BENZYL ESTER;-Benzyl 2-hydroxy-2-phenylacetate;(R)-Benzyl 2-hydroxy-2-phenylacetate;Benzyl D-(-)-Mandelate
CBNumber
CB2116376
Molecular Formula
C15H14O3
Formula Weight
242.27
MOL File
97415-09-3.mol
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D-(-)-MANDELIC ACID BENZYL ESTER Property

Melting point:
104-107 °C(lit.)
Boiling point:
387℃
Density 
1.204
refractive index 
-34 ° (C=1, CH3CN)
Flash point:
163℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
form 
powder to crystal
pka
12.15±0.20(Predicted)
color 
White to Almost white
optical activity
[α]25/D 55°, c = 1 in chloroform
CAS DataBase Reference
97415-09-3
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29181990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R549800
Product name
HYDROXY-PHENYL-ACETIC ACID BENZYL ESTER
Purity
AldrichCPR
Packaging
50MG
Price
$29.8
Updated
2024/03/01
Sigma-Aldrich
Product number
456497
Product name
Benzyl (R)-(?)-mandelate
Purity
99%
Packaging
5g
Price
$69.3
Updated
2023/06/20
TCI Chemical
Product number
M1354
Product name
Benzyl D-(-)-Mandelate
Purity
>98.0%(GC)
Packaging
5g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
M1354
Product name
Benzyl D-(-)-Mandelate
Purity
>98.0%(GC)
Packaging
25g
Price
$101
Updated
2024/03/01
Cayman Chemical
Product number
10007145
Product name
(R)-benzyl Mandelate
Purity
≥99%
Packaging
1g
Price
$11
Updated
2024/03/01
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D-(-)-MANDELIC ACID BENZYL ESTER Chemical Properties,Usage,Production

Description

(R)-benzyl Mandelate is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize:

  • (S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
  • Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
  • O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
  • Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.
It can also be used to prepare HMG-CoA reductase inhibitors.

Uses

D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis.

D-(-)-MANDELIC ACID BENZYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-(-)-MANDELIC ACID BENZYL ESTER manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
D-(-)-MANDELIC ACID BENZYL ESTER 97415-09-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Shaanxi Dideu Medichem Co. Ltd
Product
D-(-)-Mandelic acid benzyl ester 97415-09-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-01-03
Career Henan Chemical Co
Product
D-(-)-MANDELIC ACID BENZYL ESTER 97415-09-3
Price
US $20.00/KG
Min. Order
10KG
Purity
98%
Supply Ability
100kg
Release date
2018-08-01

97415-09-3, D-(-)-MANDELIC ACID BENZYL ESTERRelated Search:

L-(+)-MANDELIC ACID BENZYL ESTER PHENYL ACETATE (S)-(+)-Mandelic acid Mandelic acid DL-MANDELIC ACID BENZYL ESTER 98+%,mandelic acid benzyl ester D-LACTIC ACID-BENZYL ESTER BENZYL PHENYLACETATE Benzyl lactate (R)-3-Hydroxypiperidine hydrocloride DL-MANDELIC ACID BENZYL ESTER D-(-)-MANDELIC ACID BENZYL ESTER

  • (R)-BENZYL MANDELATE
  • D-(-)-MANDELIC ACID BENZYL ESTER
  • BENZYL D-(-)-MANDELATE
  • BENZYL (R)-(-)-MANDELATE
  • ALPHA-HYDROXY-BENZENEACETIC ACID, PHENYLMETHYL ESTER
  • benzyl (2R)-2-hydroxy-2-phenylacetate
  • Benzyl-(R)-Mandelate / Benzyl-(D)-Mandelate
  • (R)-Benzyl 2-hydroxy-2-phenylacetate
  • Benzeneacetic acid, α-hydroxy-, phenylmethyl ester, (αR)-
  • Benzyl (R)-(-)-mandelate 99%
  • Benzyl <small>D</small>-(-)-Mandelate
  • -Benzyl 2-hydroxy-2-phenylacetate
  • DOMIT-002
  • BenzylD-(-)-Mandelate&gt
  • D-(-)-MANDELIC ACID BENZYL ESTER ISO 9001：2015 REACH
  • 97415-09-3
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