D-(-)-MANDELIC ACID BENZYL ESTER
- Product Name
- D-(-)-MANDELIC ACID BENZYL ESTER
- CAS No.
- 97415-09-3
- Chemical Name
- D-(-)-MANDELIC ACID BENZYL ESTER
- Synonyms
- DOMIT-002;(R)-BENZYL MANDELATE;BENZYL D-(-)-MANDELATE;BENZYL (R)-(-)-MANDELATE;BenzylD-(-)-Mandelate>Benzyl (R)-(-)-mandelate 99%;Benzyl (R)-(?)-mandelate;D-(-)-MANDELIC ACID BENZYL ESTER;-Benzyl 2-hydroxy-2-phenylacetate;(R)-Benzyl 2-hydroxy-2-phenylacetate
- CBNumber
- CB2116376
- Molecular Formula
- C15H14O3
- Formula Weight
- 242.27
- MOL File
- 97415-09-3.mol
D-(-)-MANDELIC ACID BENZYL ESTER Property
- Melting point:
- 104-107 °C(lit.)
- Boiling point:
- 387℃
- Density
- 1.204
- refractive index
- -34 ° (C=1, CH3CN)
- Flash point:
- 163℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
- pka
- 12.15±0.20(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- optical activity
- [α]25/D 55°, c = 1 in chloroform
- CAS DataBase Reference
- 97415-09-3
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29181990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- R549800
- Product name
- HYDROXY-PHENYL-ACETIC ACID BENZYL ESTER
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- 456497
- Product name
- Benzyl (R)-(?)-mandelate
- Purity
- 99%
- Packaging
- 5g
- Price
- $69.3
- Updated
- 2023/06/20
- Product number
- M1354
- Product name
- Benzyl D-(-)-Mandelate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- M1354
- Product name
- Benzyl D-(-)-Mandelate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- 10007145
- Product name
- (R)-benzyl Mandelate
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $11
- Updated
- 2024/03/01
D-(-)-MANDELIC ACID BENZYL ESTER Chemical Properties,Usage,Production
Description
(R)-
Uses
Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize:
- (S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
- Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
- O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
- Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.
Uses
D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis.
Synthesis
611-71-2
62173-99-3
(1) Synthesis of benzyl (R)-2-hydroxy-2-phenylacetate (D-2): 85.1 g (559 mmol) of D-mandelic acid, 65 mL (628 mmol) of benzyl alcohol, and 1.01 g (5.35 mmol) of p-toluenesulfonic acid were dissolved in 700 mL of benzene, and the reaction was carried out at reflux for 6.5 hours. Upon completion of the reaction, the reaction mixture was washed with water and subsequently concentrated. The residue was recrystallized by ether to give 123.5 g (R)-benzyl 2-hydroxy-2-phenylacetate (D-2) in 91% yield. The melting point was 103.5°C-105°C. Elemental analysis (C15H14O3) Calculated values (%): C, 74.36; H, 5.82; Measured values (%): C, 74.53; H, 5.90. 1H-NMR (CDCl3-TMS) δ (ppm): 3.44 (d, J = 5.6 Hz, 1H), 5.14 (ABq, isolated, J = 12.3 Hz, 1H). J = 12.3 Hz, 1H), 5.22 (d, J = 5.6 Hz, 1H), 5.24 (ABq, Part B, J = 12.3 Hz, 1H), 7.15-7.50 (m, 10H). [α]D = -55.7 ± 1.0 (CHCl3, c = 1.003%, 24°C).
References
[1] Patent: US5047574, 1991, A
D-(-)-MANDELIC ACID BENZYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
D-(-)-MANDELIC ACID BENZYL ESTER Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
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View Lastest Price from D-(-)-MANDELIC ACID BENZYL ESTER manufacturers
- Product
- D-(-)-MANDELIC ACID BENZYL ESTER 97415-09-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- D-(-)-MANDELIC ACID BENZYL ESTER 97415-09-3
- Price
- US $20.00/KG
- Min. Order
- 10KG
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-01