5,6-DIHYDROURACIL Property

Melting point:

279-281 °C (lit.)

Boiling point:

213.59°C (rough estimate)

Density 

1.3565 (rough estimate)

refractive index 

1.4487 (estimate)

storage temp. 

2-8°C

solubility 

Soluble in Sodium Hydroxide.

form 

Solid

pka

12.10±0.20(Predicted)

color 

White to Light Beige

BRN 

112496

InChI

InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)

InChIKey

OIVLITBTBDPEFK-UHFFFAOYSA-N

SMILES

C1(=O)NCCC(=O)N1

CAS DataBase Reference

504-07-4(CAS DataBase Reference)

EPA Substance Registry System

2,4(1H,3H)-Pyrimidinedione, dihydro- (504-07-4)

Safety

Safety Statements 

24/25

WGK Germany 

3

TSCA 

Yes

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

5,6-DIHYDROURACIL Chemical Properties,Usage,Production

Chemical Properties

white to light beige crystalline powder

Uses

Impurity of Uracil.

Uses

5,6-Dihydrouracil acts as an intermediate in the catabolism of uracil.

Uses

Dihydrouracil has been used as a standard for ureido group in the colorimentric assay of transfer ribonucleic acid (tRNA).

Definition

ChEBI: 5,6-dihydrouracil is a pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a uracil.

General Description

Dihydrouracil (DiHU) is a minor base found in transfer ribonucleic acid (tRNA). It is similar to uracil with the only exception that the C₅-C₆ bond is saturated. It crystallized in the monoclinic system with space group P2₁/_C. Its crystalline structure has been analyzed. Its generation from L-cysteine and uracil via photochemical addition has been described.