ChemicalBook > CAS DataBase List > 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID

2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID

Product Name
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
CAS No.
74356-36-8
Chemical Name
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
Synonyms
ASISCHEM C71549;CHEMBRDG-BB 4019260;TIMTEC-BB SBB010333;ASINEX-REAG BAS 07567148;2,4-dimethylpyrimidine-5-carboxylicaci;2,4-dimethyl-5-pyrimidinecarboxylic acid;2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID;5-Pyrimidinecarboxylic acid, 2,4-dimethyl-;5-Pyrimidinecarboxylicacid,2,4-dimethyl-(6CI,9CI);2,4-dimethylpyrimidine-5-carboxylic acid(SALTDATA: FREE)
CBNumber
CB2117232
Molecular Formula
C7H8N2O2
Formula Weight
152.15
MOL File
74356-36-8.mol
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2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Property

Melting point:
154-155 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
299.6±20.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.62±0.25(Predicted)
Appearance
White to yellow Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
306243
Product name
2,4-Dimethyl-pyrimidine-5-carboxylic acid
Packaging
250.00mg
Price
$63
Updated
2026/05/19
Matrix Scientific
Product number
306243
Product name
2,4-Dimethyl-pyrimidine-5-carboxylic acid
Packaging
1.00g
Price
$73
Updated
2026/05/19
Matrix Scientific
Product number
306243
Product name
2,4-Dimethyl-pyrimidine-5-carboxylic acid
Packaging
5.00g
Price
$287
Updated
2026/05/19
Matrix Scientific
Product number
033134
Product name
2,4-Dimethyl-pyrimidine-5-carboxylic acid
Packaging
500.00mg
Price
$91
Updated
2026/05/18
Synthonix
Product number
D46016
Product name
2,4-Dimethyl-pyrimidine-5-carboxylic acid
Purity
98%
Packaging
1g
Price
$80
Updated
2026/05/06
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2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

2226-86-0

74356-36-8

The general procedure for the synthesis of 2,4-dimethylpyrimidine-5-carboxylic acid from ethyl 2,4-dimethylpyrimidine-5-carboxylate was as follows: potassium hydroxide (67 g, 1.0 mol) was dissolved in 95% ethanol (300 mL), and this solution was then added to a 95% ethanol (100 mL) solution of ethyl 2,4-dimethyl-5-pyrimidinecarboxylate (73 g, 0.40 mol) to the solution. The mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the ethanol was removed by evaporation under reduced pressure, the residue was dissolved in water and the aqueous solution was acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration, washed with water and dried to give 2,4-dimethylpyrimidine-5-carboxylic acid (36 g, 58% yield). The product was characterized by 1H-NMR (CDCl3), δ: 2.63 (3H, s), 2.69 (3H, s), 8.97 (1H, s).

References

[1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 295 - 305
[2] Patent: EP1402900, 2004, A1
[3] Patent: EP1364949, 2003, A1. Location in patent: Page/Page column 100
[4] Chemistry of Heterocyclic Compounds, 2007, vol. 43, # 11, p. 1479 - 1480
[5] Patent: EP2019099, 2009, A1. Location in patent: Page/Page column 15-16

2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Acetamidine hydrochloride p-Toluenesulfonic acid Toluene Sodium ethoxide Tetrahydrofuran Ethyl acetate Hydrochloric acid Methanol Sodium hydroxide N,N-Dimethylformamide dimethyl acetal Magnesium sulfate

Preparation Products

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2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Suppliers

China 59 Europe 1 India 1 Russia 1 United Kingdom 3 United States 15 Global 80
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9300
Advantage
66
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
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65
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
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China
ProdList
40000
Advantage
60
Nantong MYBio-pharm. Co., Ltd.
Tel
0513-85921823 18662920231
Fax
86-513-85012876
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sales@ntminyanmedical.com
Country
China
ProdList
4364
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Cool Pharm, Ltd
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021-60455363 18019463053
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50966098
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China
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Zhengzhou Saifun Biotechnology Co., Ltd.
Tel
022-60688926
Country
China
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60
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55
Shanghai Sainty Biotechnology Co., Ltd.
Tel
021-58957915 17721108391
Fax
QQ: 907522080
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907522080@qq.com
Country
China
ProdList
982
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55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
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market@dingdangchem.com
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China
ProdList
1854
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View Lastest Price from 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID manufacturers

Dideu Industries Group Limited
Product
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID 74356-36-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-07
Career Henan Chemical Co
Product
2,4-dimethylpyrimidine-5-carboxylic acid 74356-36-8
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

74356-36-8, 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACIDRelated Search:

4-METHYL-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID 2-(2-PYRIDINYL)-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLIC ACID ETHYL 2-METHYL-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(2-PYRIDINYL)-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE ETHYL-2,4-DIMETHYL-5-PYRIMIDINE CARBOXYLATE 2-METHYL-4-PHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL 2-PHENYL-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE 2-PHENYL-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLIC ACID BUTTPARK 86\18-12 4-AMINO-2,6-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER METHYL-2-PHENYL-4-METHYL-5-PYRIMIDINE CARBOXYLATE BUTTPARK 46\18-12 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL 4-AMINO-6-METHYL-2-(5-METHYL-4-(4-METHYLPIPERAZIN-1-YL)-2-PHENYLTHIENO[2,3-D]PYRIMIDIN-6-YL)PYRIMIDINE-5-CARBOXYLATE BUTTPARK 46\18-15 BUTTPARK 46\18-13 ETHYL 4-AMINO-2-(4-(4,6-DIMETHYLPYRIMIDIN-2-YLAMINO)-5-METHYL-2-PHENYLTHIENO[2,3-D]PYRIMIDIN-6-YL)-6-METHYLPYRIMIDINE-5-CARBOXYLATE 1-AMINO-3-PHENYL-9-OXA-2,4-DIAZA-PHENANTHREN-10-ONE

  • CHEMBRDG-BB 4019260
  • ASISCHEM C71549
  • ASINEX-REAG BAS 07567148
  • 5-Pyrimidinecarboxylicacid,2,4-dimethyl-(6CI,9CI)
  • TIMTEC-BB SBB010333
  • 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
  • 2,4-dimethyl-5-pyrimidinecarboxylic acid
  • 2,4-dimethylpyrimidine-5-carboxylic acid(SALTDATA: FREE)
  • 2,4-dimethylpyrimidine-5-carboxylicaci
  • 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH
  • 5-Pyrimidinecarboxylic acid, 2,4-dimethyl-
  • 74356-36-8
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrimidine
  • CARBOXYLICACID
  • pharmacetical
  • Pyrimidine series
  • Carboxylic Acids
  • Pyrazines, Pyrimidines & Pyridazines
  • Carboxylic Acids