Dicentrin

ChemicalBook > CAS DataBase List > Dicentrin

Description Anti-cancer Activity

Product Name: Dicentrin
CAS No.: 517-66-8
Chemical Name: Dicentrin
Synonyms: Nsc406035;dicentrine;DICENTRINE95%;(S)-dicentrine;o,N-Dimethyllitseferine;1,2-Methylenedioxy-9,10-dimethoxyaporphine;9,10-Dimethoxy-1,2-(methylenedioxy)aporphine;9,10-Dimethoxy-1,2-(methylenedioxy)-6aalpha-aporphine;1,2-(Methylenedioxy)-9,10-dimethoxy-6aalpha-aporphine;6A.alpha.-Aporphine, 9,10-dimethoxy-1,2-(methylenedioxy)-
CBNumber: CB21178489
Molecular Formula: C20H21NO4
Formula Weight: 339.39
MOL File: 517-66-8.mol

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Dicentrin Property

Melting point:: 177-178℃
Boiling point:: 481℃
Density: 1.266
refractive index: 1.6250 (estimate)
Flash point:: 143℃
storage temp.: 4°C, protect from light
solubility: Soluble in DMSO
pka: 6.65±0.20(Predicted)
form: Solid
color: Off-white to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0026026
Product name: Dicentrine
Packaging: 1mg
Price: $171
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016457
Product name: DICENTRINE
Purity: 95.00%
Packaging: 5MG
Price: $504.69
Updated: 2021/12/16

ChemScene

Product number: CS-0026026
Product name: Dicentrine
Packaging: 5mg
Price: $514
Updated: 2021/12/16

AvaChem

Product number: 2300
Product name: Dicentrine
Packaging: 1mg
Price: $190
Updated: 2021/12/16

Arctom

Product number: CFN92331
Product name: Dicentrine
Packaging: 5mg
Price: $318
Updated: 2021/12/16

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Dicentrin Chemical Properties,Usage,Production

Description

D-Dicentrine is an aporphinic alkaloid found in several plant species, mainly from family Lauraceae, including Lindera megaphylla. D-Dicentrine shows antinociceptive activity in a mouse model of pain. It probably acts via a TRPA1-dependent mechanism. D-Dicentrine is an alpha 1-adrenoceptor antagonist effective against human hyperplastic prostates.

Anti-cancer Activity

D-Dicentrine, a naturally occurring aporphine type isoquinoline alkaloid, isolated from the root of Lindera megaphylla Hemsl. (Lauraceae), was evaluated for its potential anti-cancer activity. Huang RL etc. found d-dicentrine significantly inhibited the growth of human hepatoma cell line HuH-7 by delaying its doubling time in tissue culture. An in vitro colony forming assay showed that d-dicentrine decreased the colony formation efficiency in both hepatoma cell lines, HuH-7 and MS-G2, used in our study.

Uses

d-Dicentrine is a natural aporphine alkaloid extracted from the root of L. megaphylla which displays antitumor effects through inhibition of topoisomerase II.

Definition

ChEBI: Dicentrine is an aporphine alkaloid.

Dicentrin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dicentrin Suppliers

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517-66-8, DicentrinRelated Search:

CURINE corydalmine [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline VERATRIDINE daurisoline veratramine VERATRINE L-Hyoscyamine Xanthiazone menisdaurin Xanthiside 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Daurinoline

DICENTRINE95%

dicentrine

(7aS)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline

1,2-Methylenedioxy-9,10-dimethoxyaporphine

5H-Benzo[G]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7A,8-tetrahydro-10,11-dimethoxy-7-methyl-, (S)-

6A.alpha.-Aporphine, 9,10-dimethoxy-1,2-(methylenedioxy)-

9,10-Dimethoxy-1,2-(methylenedioxy)aporphine

Nsc406035

o,N-Dimethyllitseferine

1,2-(Methylenedioxy)-9,10-dimethoxy-6aalpha-aporphine

9,10-Dimethoxy-1,2-(methylenedioxy)-6aalpha-aporphine

5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline,6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-, (7aS)-

(S)-dicentrine

517-66-8