corydalmine

Product Name: corydalmine
CAS No.: 30413-84-4
Chemical Name: corydalmine
Synonyms: Kikemanin;Kikemanine;Schefferine;corydalmine;(-)-Kikemanine;(-)-Corydalmine;(13aS)-5,8,13,13a-Tetrahydro-2,3,9-trimethoxy-6H-dibenzo[a,g]quinolizin-10-ol;6H-Dibenzo[a,g]quinolizin-10-ol,5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (13aS)-;(13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol
CBNumber: CB81358807
Molecular Formula: C20H23NO4
Formula Weight: 341.4
MOL File: 30413-84-4.mol

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corydalmine Property

Melting point:: 177-178℃
Boiling point:: 501.2±50.0 °C(Predicted)
Density: 1.29
storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 9.97±0.20(Predicted)
InChI: InChI=1S/C20H23NO4/c1-23-18-9-13-6-7-21-11-15-12(4-5-17(22)20(15)25-3)8-16(21)14(13)10-19(18)24-2/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1
InChIKey: DIHXHTWYVOYYDC-INIZCTEOSA-N
SMILES: C12=CC(OC)=C(OC)C=C1CCN1[C@@]2([H])CC2=CC=C(O)C(OC)=C2C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Arctom

Product number: CFN98384
Product name: Corydalmine
Purity: ≥98%
Packaging: 5mg
Price: $513
Updated: 2021/12/16

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corydalmine Chemical Properties,Usage,Production

Uses

Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

in vivo

Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes^[2].

target

P450 (e.g. CYP17) | Antifection

IC 50

CXCR2

References

[1] S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. DOI:10.4489/MYCO.2007.35.2.069
[2] Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. DOI:10.1016/j.jpba.2016.05.024
[3] Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47. DOI:10.1016/j.neuropharm.2018.03.004

corydalmine Preparation Products And Raw materials

Raw materials

Preparation Products

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corydalmine Suppliers

China 81 United States 5 Global 86

Naturewill Biotechnology Co., Ltd.

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30413-84-4, corydalmineRelated Search:

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corydalmine

(-)-Kikemanine

(13aS)-5,8,13,13a-Tetrahydro-2,3,9-trimethoxy-6H-dibenzo[a,g]quinolizin-10-ol

Kikemanin

Kikemanine

Schefferine

6H-Dibenzo[a,g]quinolizin-10-ol,5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (13aS)-

(13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol

(-)-Corydalmine

30413-84-4