Description Appearance Uses In vivo research Preparation
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Tetrahydropalmatine

Description Appearance Uses In vivo research Preparation
Product Name
Tetrahydropalmatine
CAS No.
2934-97-6
Chemical Name
Tetrahydropalmatine
Synonyms
ROTUNDINUM;AKOS 208-04;ROTUNDIN HYDRATE;Rotundine CP2000;Tetrahydropalmatine;TETRAHYDROPALMITINE;TETRAHYDROPALMATINE;L-TETRAHYDROPALMATINE;Rafoxanide Impurity 5;DL-TETRAHYDROPALMATINE
CBNumber
CB4157652
Molecular Formula
C21H25NO4
Formula Weight
355.43
MOL File
2934-97-6.mol
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Tetrahydropalmatine Property

Melting point:
155℃
Boiling point:
482.9±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Solid
pka
6.53±0.20(Predicted)
color 
White to Pale Yellow
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3650
Product name
Tetrahydropalmatine
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$76
Updated
2024/03/01
TCI Chemical
Product number
T3650
Product name
Tetrahydropalmatine
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$150
Updated
2024/03/01
Alfa Aesar
Product number
J63328
Product name
Tetrahydropalmatine
Purity
98%
Packaging
1g
Price
$58.65
Updated
2024/03/01
Alfa Aesar
Product number
J63328
Product name
Tetrahydropalmatine
Purity
98%
Packaging
5g
Price
$225.65
Updated
2024/03/01
Usbiological
Product number
300544
Product name
L-Tetrahydropalmatine
Packaging
20mg
Price
$349
Updated
2021/12/16
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Tetrahydropalmatine Chemical Properties,Usage,Production

Description

Tetrahydropalmatine can be prepared from the total bases of tetrahydroxy berberine. Tetrahydropalmatine can be used to prepare palmatine. Palmatine has a broad-spectrum antibacterial effect, especially against Candida albicans. It can be used clinically to treat gynecological inflammation, bacillary dysentery, enteritis, respiratory and urinary tract infections, surgical infections, and conjunctivitis. Palmatine can also enhance the relaxation of the body's norepinephrine smooth muscle.
Tetrahydropalmatine, an active component isolated from corydalis, acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Appearance

White to Orange to Green powder to crystal

Uses

DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

In vivo research

Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin.

Preparation

A. Berberine hydrochloride is ring-opened under the conditions of p-toluenesulfonic acid, xylene, and HCl at 70°C to obtain desmethylene berberine hydrochloride.
B. Demethylene berberine hydrochloride is methyl etherified with potassium carbonate, methanol, and dimethyl sulfate at 40°C to obtain palmatine hydrochloride.
C. Palmatine hydrochloride is racemized under the conditions of methanol and sodium borohydride to obtain tetrahydropalmatine.

Uses

analgesic, hypnotic, papaverine-like

Uses

DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

Definition

ChEBI: 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline is an alkaloid.

Tetrahydropalmatine Preparation Products And Raw materials

Raw materials

Preparation Products

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Tetrahydropalmatine Suppliers

TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
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View Lastest Price from Tetrahydropalmatine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
DL-tetrahydropalMatine 2934-97-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
100KGS
Release date
2021-07-19
Shaanxi Haibo Biotechnology Co., Ltd
Product
Corydalis yanhusuo extract Tetrahydropalmatine powder 2934-97-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
10: 1,Lepidium meyenii Walp
Supply Ability
10000kg/Month
Release date
2023-09-11
Shanghai Standard Technology Co., Ltd.
Product
Tetrahydropalmatine 2934-97-6
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-24

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