2-FLUORO-6-METHOXYPHENOL

Product Name: 2-FLUORO-6-METHOXYPHENOL
CAS No.: 73943-41-6
Chemical Name: 2-FLUORO-6-METHOXYPHENOL
Synonyms: 2-FLUORO-6-METHOXYPHENOL;2-Methoxy-6-fluorophenol;2-Hydroxy-3-fluoroanisole;Phenol, 2-fluoro-6-methoxy-;2-Fluoro-6-methoxyphenol98%;2-Fluoro-6-methoxyphenol 98%
CBNumber: CB2118840
Molecular Formula: C7H7FO2
Formula Weight: 142.13
MOL File: 73943-41-6.mol

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2-FLUORO-6-METHOXYPHENOL Property

Boiling point:: 130-131 °C36 mm Hg(lit.)
Density: 1.23 g/mL at 25 °C(lit.)
refractive index: n20/D 1.52(lit.)
Flash point:: 218 °F
storage temp.: Inert atmosphere,Room Temperature
pka: 8.71±0.10(Predicted)
form: Liquid
color: Clear colorless to light brown
Specific Gravity: 1.230
InChI: InChI=1S/C7H7FO2/c1-10-6-4-2-3-5(8)7(6)9/h2-4,9H,1H3
InChIKey: YZNHPLVFLRSVHY-UHFFFAOYSA-N
SMILES: C1(O)=C(OC)C=CC=C1F
CAS DataBase Reference: 73943-41-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29095000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: F597528
Product name: 2-Fluoro-6-methoxyphenol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: F597528
Product name: 2-Fluoro-6-methoxyphenol
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: F597528
Product name: 2-Fluoro-6-methoxyphenol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 008959
Product name: 2-Fluoro-6-methoxyphenol
Purity: 98%
Packaging: 1g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2601-3-44
Product name: 2-Fluoro-6-methoxyphenol
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2021/12/16

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2-FLUORO-6-METHOXYPHENOL Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light brown liquid

Synthesis

456-49-5

73943-41-6

The general procedure for the synthesis of 2-fluoro-6-methoxyphenol from m-fluoroanisole was as follows: 4.0 mL (9.4 mmol) of 2.36 M n-butyllithium solution was slowly added dropwise over a period of 1 h to 10.0 mL of anhydrous tetrahydrofuran (THF) solution containing 1.28 g (10 mmol) of m-fluoroanisole (1) according to the method of Ladd and Weinstock The reaction temperature was maintained below -65 °C and cooled using a dry ice/acetone bath. The reaction mixture was stirred at -78 °C and under nitrogen protection for 2 hours. Subsequently, 1.17 g (11 mmol) of trimethoxyborane dissolved in 2.00 mL of anhydrous THF was added dropwise over 1 h at -78 °C and stirring was continued at -78 °C for 30 min. The reaction mixture was slowly warmed to 0 °C and 0.88 mL (15 mmol) of glacial acetic acid was added, followed by the dropwise addition of 1 mL (10 mmol) of 30% hydrogen peroxide (H2O2) solution. The reaction mixture was stirred at 25 °C overnight. After completion of the reaction, the reaction solution was diluted with 10 mL of water and extracted with THF (2 × 10 mL). The organic phases were combined and washed sequentially with H2O (2 × 7 mL) and 10% brine (2 × 3 mL). The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give 1.16 g (80% yield) of 2-fluoro-6-methoxyphenol. The yields of successive replicate experiments were as follows: 15.5 g of product (63% yield) was obtained from 174 mmol of feedstock; 29.7 g of product (80% yield) was obtained from 261 mmol of feedstock. The structures of the products were analyzed by 1H NMR (300 MHz, CDCl3) δ 6.82-6.63 (m, 1H), 5.51 (s, 1H), 3.90 (s, 1H); 19F NMR (282 MHz, CDCl3) δ -137.61 ppm (m, 1F); EI-MS: m/z 142 (M+), 127.

References

[1] Synlett, 2014, vol. 25, # 20, p. 2891 - 2894
[2] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0405
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 8, p. 2204 - 2211
[4] Journal of Organic Chemistry, 1981, vol. 46, # 1, p. 203 - 206
[5] Journal of Chemical Research, Miniprint, 1986, # 1, p. 171 - 193

2-FLUORO-6-METHOXYPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-6-METHOXYPHENOL Suppliers

China 86 France 1 Germany 2 India 3 Switzerland 1 United Kingdom 4 United States 16 Global 113

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View Lastest Price from 2-FLUORO-6-METHOXYPHENOL manufacturers

Career Henan Chemical Co

Product: 2-FLUORO-6-METHOXYPHENOL 73943-41-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-12-18

73943-41-6, 2-FLUORO-6-METHOXYPHENOLRelated Search:

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2-FLUORO-6-METHOXYPHENOL

2-Fluoro-6-methoxyphenol 98%

2-Fluoro-6-methoxyphenol98%

2-Hydroxy-3-fluoroanisole

2-Methoxy-6-fluorophenol

Phenol, 2-fluoro-6-methoxy-

73943-41-6

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